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ProteomicsEndosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity
Multi-epitope affinity purification mass spectrometry (meAP-MS) analysis of TMEM9-, TMEM9B- and CLC3- associated proteins from solubilized mouse brain membranes identified chloride channel subtypes CLCN3, 4 and 5 as exclusive interaction partners of TMEM9 and TMM9B.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD061285 | Pride
Ap-ms Chloride channels Membrane protein complex Auxiliary subunits Mouse brain Protein-protein interactions 
GenomicsNext Generation Sequencing Quantitative Analysis of Wild Type and TMEM9 KD Transcriptomes
Next Generation Sequencing Quantitative Analysis of Wild Type and TMEM9 KD Transcriptomes
PRJNA812938 | ENA
TranscriptomicsNext Generation Sequencing Quantitative Analysis of Wild Type and TMEM9 KD Transcriptomes
Purpose: The goals of this study are to check signaling pathway change upon TMEM9 KD using NGS-derived retinal transcriptome profiling (RNA-seq). Methods: Retinal mRNA profiles of MDA-MB-453 WT and TMEM9 KD were generated by deep sequencing, using Illumina. The sequence reads that passed quality fil...
ORGANISM(S): Homo sapiens 
2023-03-03 | GSE197959 | GEO
ProteomicsCharacterization of endosomes and interactions from TMEM230 and TMEM9/9B mutants in human neurons
EndoMAP aims to systematically dissect the human endosomal protein complexes. To examine TMEM9 and TMEM230 interactions, we generated TMEM230 and TMEM9 knockouts (KOs) using CRISPR/Cas9 in human embryonic stem (ES) cells and converted the cells to induced neurons (iNeurons). TMEM230 and TMEM9 were i...
ORGANISM(S): Homo sapiens (Human) 
2025-03-29 | PXD054765 | Pride
Tmt Human Tmem9 Endosomes Ineurons Tmem230 Endomap 
UnknownTMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling.
Not available
S-EPMC6261670 | biostudies-literature
UnknownTMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression.
Not available
S-EPMC11045738 | biostudies-literature
UnknownTMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Not available
S-EPMC7647947 | biostudies-literature
UnknownStructural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P<sub>2</sub>.
Not available
S-EPMC11908120 | biostudies-literature
UnknownEndosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity.
Not available
S-EPMC11962092 | biostudies-literature
UnknownStructural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P<sub>2</sub>.
Not available
S-EPMC12403049 | biostudies-literature
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