Tnf receptor-associated factor 6 (traf6)

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Unknown (174)
Transcriptomics (29)
Genomics (7)
Proteomics (7)
Other (1)
Metabolomics (1)

Organisms

Homo sapiens (17)
Mus musculus (12)
Penicillium verrucosum (4)
uncultured Desulfatiglans sp. (4)
Cellulophaga baltica NN016038 (4)
Fibrobacter succinogenes subsp. succinogenes S85 (4)
Yersinia ruckeri (4)
Fusarium cf. oxysporum (4)
Candidatus Ethanoperedens thermophilum (4)
Bifidobacteriaceae (4)
Physeter macrocephalus (4)
Elephas maximus indicus (4)
Klebsiella pneumoniae subsp. pneumoniae CIP 52.145 = B5055 (4)
Caretta caretta x Chelonia mydas (4)
Homininae (4)
Baylisascaris procyonis (4)
Microcystis aeruginosa PCC 7806SL (4)
Enhydra lutris nereis (4)
Sporothrix sp. (4)
Aspergillus oryzae var. oryzae (4)
Broussonetia papyrifera (4)
Nostoc sp. FB71 (4)
Musa (4)
Loxosceles intermedia (4)
NEWT:46170 (4)
Sepia officinalis (4)
Mustela sp. (4)
Nostoc sp. (4)
Danio rerio (3)
Rattus norvegicus (1)

Organisms

Mus musculus (5)
Rattus norvegicus (1)

Repository

biostudies-arrayexpress (26)
ENA (6)
geo (5)
pride (4)
iProX (1)
jPOST (1)
MassIVE (1)
MetaboLights (1)

Tissue

Early embryonic cell (1)
Fibroblast (1)
Brain (1)
Cell culture (1)

Technology Type

Mass Spectrometry (4)
Affinity purification coupled with mass spectrometry proteomics (3)
Mass spectrometry (1)
Shotgun proteomics (1)

Instrument Platform

Illumina HiSeq 2000 (1)
LTQ (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)

Publication Date

2015 (5)
2010 (5)
2009 (5)
2018 (4)
2013 (3)
2024 (3)
2022 (3)
2016 (2)
2012 (2)
2020 (2)
2019 (1)
2014 (1)
2011 (1)
2008 (1)
2025 (1)

Metabolite Name

[(2S,3R,4S,5S)-3-[(2S,3R,4R,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl] (4aS,6aS,6bR,10S,12aR,14bS)-10-[(2R,3R,4S,5S,6R)-4-hydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate_30.2% (1)
NCGC00025125-21!N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide [IIN-based on: CCMSLIB00000845970] (1)
NCGC00380698-01_C24H30O13_Cyclopenta[c]pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-4a-hydroxy-7-methyl-5-oxo-, 2-(3,4-dihydroxyphenyl)ethyl ester, (1S,4aR,7aR)- (1)
(G)(NAM)-AemA;(3s-4)-(G)(NAM)-AemA (1)
MMV676480 (1)
Flavone base + 3O, 2MeO, O-guaiacylglyceryl-Hex (1)
NCGC00347420-02_C39H65NO12_15-Hydroxyspirosolan-3-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside (1)
NCGC00381337-01_C64H104O30_Pentopyranosyl-(1->4)pentopyranosyl-(1->4)-1-O-[(3beta,5xi,9xi,18xi)-3-{[hexopyranosyl-(1->3)hexopyranosyl-(1->4)-6-deoxyhexopyranosyl]oxy}-28-oxoolean-12-en-28-yl]hexopyranose (1)
(7S,9E,11S,12R,13S,14S,15S,16R,17S,18S,19E,21Z)-26-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,2... (1)
NCGC00380818-01_C17H15ClO6_7-Chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexa[2,5]diene]-3,4'-dione (1)
MGDG (18:3/18:4)_(2S)-1-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(6Z,9Z,12Z,15Z-octa-decatetranoyl)-3-beta-D-galacto-pyranosyl-sn-glycerol (1)
(NAG)(NAM)-AeKA[3-NH2-GGGG] (1)
NCGC00347534-02![2-[4-hydroxy-2,5-bis(hydroxymethyl)-3-(2-methylpropanoyloxy)oxolan-2-yl]oxy-6-(hydroxymethyl)-4,5-bis(2-methylpropanoyloxy)oxan-3-yl] decanoate [IIN-based on: CCMSLIB00000848581] (1)
Methyl 2-(3,5-dichloro-2-hydroxy-6-methoxy-4-methylbenzoyl)-3,5-dihydroxybenzoate (1)
Pesticide3_Chlorfluazuron_C20H9Cl3F5N3O3_Benzamide, N-[[[3,5-dichloro-4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]amino]carbonyl]-2,6-difluoro- (1)
NCGC00385692-01_C44H68O14_3-Hydroxyspirosta-5,25(27)-dien-1-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-(2-hydroxy-3-methylpentanoyl)-alpha-L-arabinopyranoside (1)
NCGC00384992-01_C20H26O6_ (1)
(NAG)(NAM)-AemAG;(3s-4)-(G)(NAM)-AemA (1)
Solanidine base + O-Hex-Hex (1)
(2S,3R,4S,5R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,6S,8R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol (1)
NCGC00380130-01_C15H26O4_1,2-Naphthalenedimethanol, 1,4,4a,5,6,7,8,8a-octahydro-1,4-dihydroxy-5,5,8a-trimethyl- (1)
NCGC00169037-02_C25H34O8_beta-D-Glucopyranoside, 5-(4-hydroxyphenyl)-1-[2-(4-hydroxyphenyl)ethyl]pentyl (1)
NCGC00347542-02!4-[5-(3,4-dimethoxyphenyl)-3,4-dimethyloxolan-2-yl]phenol [IIN-based on: CCMSLIB00000848919] (1)
NCGC00381245-01_C22H30O8_2-[6-{[(2Z)-4-Acetoxy-2-methyl-2-butenoyl]oxy}-2-hydroxy-3-(3-hydroxy-1-propen-2-yl)-4-methyl-4-vinylcyclohexyl]acrylic acid (1)
(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-((3-(benzo[d][1,3]dioxol-5-yl)-6-ethyl-2-methyl-4-oxo-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (1)
(3?,5?,9?,16?,18?,22?)-22-Acetoxy-16-hydroxy-13,28-epoxyoleanan-3-yl 6-deoxy-?-L-mannopyranosyl-(1->2)-?-D-galactopyranosyl-(1->3)-[?-D-glucopyranosyl-(1->2)]-?-D-glucopyran osiduronic acid_major (1)
NCGC00386015-01_C32H44O8_Estra-1,5-diene-3,11-dione, 17-[(1R,3E)-1-(acetyloxy)-5-hydroxy-1,5-dimethyl-2-oxo-3-hexen-1-yl]-2,16-dihydroxy-4,4,9,14-tetramethyl-, (9beta,10alpha,16alpha,17beta)- (1)
N-ACETYL-D-MANNOSAMINE (1)
NCGC00169946-02!2-(1,2-dihydroxypentyl)-4-methoxy-2,3-dihydropyran-6-one [IIN-based: Match] (1)
NCGC00169288-03_C21H26O9_(1aS,3R,4R,5S,5aS,8aR,10R,10aS)-4-Acetoxy-3-hydroxy-3,10-dimethyl-6-methylene-2,7-dioxododecahydrooxireno[7,8]cyclodeca[1,2-b]furan-5-yl methacrylate (1)

First Public Date

2018 (3)
2022 (2)
2024 (1)

Study type

Transcription profiling by array (18)
RNA-seq of coding RNA (4)
Comparative genomic hybridization by array (3)
ChIP-chip by array (1)

Release Date

2022 (24)
2023 (20)
2021 (18)
2020 (18)
2019 (13)
2015 (11)
2018 (11)
2017 (11)
2014 (10)
2024 (10)
2013 (9)
2012 (9)
2016 (8)
2010 (8)
2011 (5)
2009 (5)
2025 (4)
2008 (3)
2007 (2)
2003 (1)

Lab affiliation

MRC Protein Phosphorylation and Ubiquitylation Unit, The Sir James Black Centre, University of Dundee, United Kingdom (1)
Crick Mass Spectrometry STP (1)
National Research Council Ottawa, Canada (1)
Academia Sinica,Institute of Biological Chemistry (1)

Tags

xref:PubMed:29386112 (1)
xref:PubMed:35496311 (1)
xref:PubMed:29406859 (1)
xref:PubMed:30260972 (1)
xref:PubMed:39083380 (1)

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Traf6 function in the innate immune response of zebrafish embryos

Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. Two-way factorial dual colour design with factor 1 'infection with Salmonella ...

ORGANISM(S): Danio rerio

2010-08-01 | E-GEOD-20310 | biostudies-arrayexpress

Traf6 function in the innate immune response of zebrafish embryos

Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. All infection experiments were performed using mixed egg clutches of ABxTL str...

ORGANISM(S): Danio rerio

2010-08-01 | E-GEOD-21024 | biostudies-arrayexpress

Transcription profiling of mouse CD8 T cells from two mouse strains (OTI-WT and OTI-TRAF6 knockout) at two timepoints

CD8 T cells play a crucial role in immunity to infection and cancer. They are maintained in constant numbers, but upon stimulation with antigen undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific populations, followed ...

ORGANISM(S): Mus musculus

2009-06-24 | E-GEOD-15750 | biostudies-arrayexpress

Misfolded SOD1 binds the ubiquitin ligase TRAF6

Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the selective loss of motor neurons. Mutations in Cu/Zn superoxide dismutase (SOD1) are the second most common cause of ALS and it is now well accepted that they result in a gain of toxicity due to protein misfolding. We previo...

ORGANISM(S): Rattus norvegicus (Rat)

2020-02-24 | PXD015279 | Pride

Identification of proteins that interact with TRAF6 in ADP-heptose- or IL-1β-stimulated HEK293 cells

The bacterial metabolite ADP-heptose activates the mammalian protein kinase ALPK1 (alpha protein kinase 1), which then phosphorylates TIFA (TRAF interacting protein with FHA domain). This leads to the oligomerisation of TIFA and the recruitment and oligomerisation of TRAF6 (TNF receptor-associated f...

ORGANISM(S): Homo sapiens (Human)

2022-09-14 | PXD034964 | Pride

Adp-heptose Traf6 Tifa Alpk1

Wogonoside inhibits TNF receptor-associated factor 6 (TRAF6) mediated-tumor microenvironment and prognosis of pancreatic cancer.

Not available

S-EPMC8506702 | biostudies-literature

Exploring the Effects and Mechanisms of Curcumin on Proliferation, Apoptosis, and Oxidative Stress in Hepatoblastoma cell line via the TLR4/TRAF6/MAPKs Pathway

A combination of bioinformatics and network pharmacology was used to screen curcumin's target genes and related signaling pathways in treating hepatocellular carcinoma. Curcumin-Containing Serum（CUR） was prepared. Cisplatin(CDDP) served as the positive control .The CCK-8 assay, scratch assay, and...

2025-11-28 | MTBLS13412 | MetaboLights

K48/K63-linked polyubiquitination of ATG9A at K581/K838 by TRAF6 E3 ligase

Excessive generation and accumulation of highly reactive oxidizing molecules causes oxidative stress and oxidative damage to cellular components. Accumulating evidence indicates that autophagy diminishes oxidative damage in cells and maintains redox homeostasis by degrading and recycling intracellul...

ORGANISM(S): Homo sapiens (Human)

2022-02-24 | PXD030415 | Pride

Ubiquitin Traf6 Atg9a

Transcriptome analysis of Traf6 function in early zebrafish embryogenesis

In order to study Traf6 function during early zebrafish embryogenesis, transcriptome expression profiling was performed at 30% epiboly using a morpholino based knock-down approach. Two-factorial design with the factors 'Treatment' (5 levels:'Phenol Red', 'Standard Control', 'Mismatch', 'Morpholino1'...

ORGANISM(S): Danio rerio

2013-12-01 | E-GEOD-42856 | biostudies-arrayexpress

Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling.

Not available

S-EPMC4571974 | biostudies-literature

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