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TranscriptomicsTranscriptional profiling of HT-29 cells stimulated with pairwise combinations of TNF, EGF, and insulin
The objective of this study was to investigate the link between signaling-network activation and transcriptional regulation downstream of tumor necrosis factor (TNF), epidermal growth factor (EGF), and insulin. Microarrays were used to capture the transcriptional responses to TNF, EGF, and insulin a...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-69639 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of inducible GATA6L-overexpressing HT-29 cells stimulated with TNF
The objective of this study was to investigate the role of GATA6L with or without TNF stimulation. Microarrays were used to capture the transcriptional response to GATA6L overpexression at intermediate times after TNF stimulation. Cells were induced for GATA6L overexpression and evaluated at two hou...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-72079 | biostudies-arrayexpress
TranscriptomicsEffect of human TNF-alpha on adult Schistosoma mansoni gene expression profile
Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response whe...
ORGANISM(S): Schistosoma mansoni 
2010-06-24 | E-GEOD-16261 | biostudies-arrayexpress
ModelsHayashi2013 - TNF-induced Signaling Dynamics (Model A)
Hayashi2013 - TNF-induced Signaling Dynamics Model (Model A) Tumor necrosis factor (TNF) plays a crucial role in inflammation and is associated with diseases such as rheumatoid arthritis and cancer. While TNF signaling pathways are well studied, targeted regulation of proinflammatory responses rem...
2025-02-19 | MODEL2502170001 | BioModels
TranscriptomicsTranscription profiling by array of siRNA transfected HEK293T cells untreated or treated with TNF-alpha to study the effect of siRNA-mediated knockdown of different genes
HEK293T cells were treated with TNF-alpha for different periods of time to study the effect of siRNA-mediated knockdown of different genes (negative control: Renilla luciferase; positive controls: TNFRSF1A, RelA; gene of interest: CASP4) on TNF-induced gene expression
ORGANISM(S): Homo sapiens 
2012-07-06 | E-MTAB-900 | biostudies-arrayexpress
TranscriptomicsMiR-26 dampens IL-6 production by down-regulating TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA
We found NF-kB signaling as a major target of miR-26 based on an analysis of the changes in gene activation by TNF-a in response to alteration of miR-26 levels. Transcriptional profiling of genes in response to either a miR-26 mimic or miR-26 antagomir.
ORGANISM(S): Homo sapiens 
2016-03-31 | E-GEOD-70831 | biostudies-arrayexpress
ModelsHayashi2013 - Extended TNF-induced Signaling with Gene Expression Dynamics (Model B)
Hayashi2013 - Extended TNF-induced Signaling with Gene Expression Dynamics (Model B) Tumor necrosis factor (TNF) plays a crucial role in inflammation and is associated with diseases such as rheumatoid arthritis and cancer. While TNF signaling pathways are well studied, targeted regulation of proin...
2025-02-19 | MODEL2502170002 | BioModels
TranscriptomicsModulation of the TNF-induced macrophage response by synovial fibroblasts
Here we explored how the human macrophage response to tumor necrosis factor (TNF) is regulated by human synovial fibroblasts, the representative stromal cell type in the synovial lining of joints that become activated during inflammatory arthritis. Genome-wide transcriptome analysis (RNAseq) showed ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-57723 | biostudies-arrayexpress
ProteomicsPhosphoproteome profiling uncovers a key role for CDKs in TNF signaling
Tumor necrosis factor (TNF) is one of the few cytokines successfully targeted by therapies against inflammatory diseases. However, blocking this well studied and pleiotropic ligand can cause dramatic side-effects. We reasoned that a systems-level proteomic analysis of TNF signaling could dissec...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-10-11 | PXD021366 | Pride
Necroptosis Transcription Kinases Apoptosis Phosphoproteomics Spatial proteomics Cyclin-dependent kinases Tnf Cell death 
ProteomicsSPATA2 links CYLD to the TNF-a receptor signaling complex and modulates the receptor signaling outcomes
TNF-a is a key regulator of innate immune and proinflammatory responses. However, the composition of the TNF-a receptor associated signaling complexes (TNF-RSC) and the architecture of the downstream signaling networks are incompletely understood. We employed quantitative mass spectrometry to demons...
ORGANISM(S): Homo sapiens (Human) 
2016-06-09 | PXD003627 | Pride
Necroptosis Tnf-alpha Nf-kappab Phosphorylation Ubiquitin 
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