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TranscriptomicsTranscription profiling of Jurkat T cell line and mouse thymocytes
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligandindependent signaling by the precursors of mature...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-SMDB-2194 | biostudies-arrayexpress
ProteomicsFusidic acid resistance through changes in the dynamics of EF-G
HDX-MS was used to study the binding of FusB to EF-G
ORGANISM(S): Staphylococcus aureus 
2020-10-15 | PXD017491 | Pride
E coli 
ProteomicsCharacterisation of TACC3 affimer interactions by HDX-MS
Here we characterise the interactions of affimers against TACC3 by HDX-MS.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052409 | Pride
Hdx Taac3 Affimer 
ProteomicsAffimer reagents as tools to modulate GPVI-ligand interactions
We have isolated Affimers that bind to GPVI and characterized their effect on receptor function. An affimer that binds specifically to dimeric GPVI was identified as a novel tool to detect dimeric GPVI. The binding sites of the different Affimers were mapped using HDX-MS, revealing that they interac...
ORGANISM(S): Homo sapiens (Human) 
2024-10-01 | PXD046982 | Pride
Hdx-ms Gpvi 
UnknownLeukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
Not available
S-EPMC2680140 | biostudies-literature
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: siEYA4 pY IP-MS
The Eyes Absent family of proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour promoting across a range of cancer types. To date, the molecular targets of EYA phosphatase activity remain largely uncharacterised. Here, we identify Polo-like kinase 1 (PLK1) as...
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD036430 | Pride
Py ip Eya4 
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: EYA4 BioID
The aim of this project was to identify the EYA4 interactome. This was part of a larger research goal of identifying EYA4 phosphatase substrates and the cell biological consequences of their dephosphorylation.
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD036405 | Pride
Eya4 Bioid 
ProteomicsTetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex
A disintegrin and metalloprotease 10 (ADAM10) is essential for embryonic development and impacts on diseases such as cancer, Alzheimer’s and inflammatory diseases. ADAM10 is a ‘molecular scissor’ that proteolytically cleaves the extracellular region from over 100 substrates, including Notch, amyloi...
ORGANISM(S): Homo sapiens (Human) 
2021-08-24 | PXD016508 | Pride
Tspan15 Adam10 
UnknownA polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.
Not available
S-EPMC4471812 | biostudies-literature
UnknownGuideline for the management of fatigue in children and adolescents with cancer or pediatric hematopoietic cell transplant recipients: 2023 update.
Not available
S-EPMC10440444 | biostudies-literature
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