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BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Gut microbiota dysbiosis and metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLT...

2023-02-02 | MTBLS6736 | MetaboLights
Cell cycle arrest and transcriptional responses to ionizing radiation (IR)-induced DNA damage were quantified in telomerase-expressing human diploid fibroblasts. Assays of clonal expansion established 1.5 Gy IR as the D0 dose in three fibroblast lines and this dose was used in all subsequent analyse...
ORGANISM(S): Homo sapiens 
The changes in global gene expression in response to DNA damage may derive from either direct induction or repression by transcriptional regulation or indirectly by synchronization of cells to specific cell cycle phases, such as G1 or G2. We developed a model that successfully estimated the express...
ORGANISM(S): Homo sapiens 
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA...
ORGANISM(S): Homo sapiens 
Increasing evidence has demonstrated that tumor-initiating cells (TICs) contribute to tumor initiation and therapy resistance through dysregulation of kinase signaling. However, the intertwined networks of many kinases and their functional downstream targets are yet to be revealed and fully characte...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067039 | Pride
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints...
ORGANISM(S): Homo sapiens 
This project presents a quantitative proteomics analysis of co-cultured Chlorella sp. and Symbiodinium sp. under UV-B irradiation. The algae were exposed to UV-B radiation at an intensity of 5.7 kJ/m²/h for a duration of 10 hours. Samples were collected immediately after the exposure to investigate ...
ORGANISM(S): Unclassified Chlorella <ncbi:txid1962113> Unclassified Symbiodinium 
2025-12-22 | PXD072317 |
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