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ProteomicsTousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication
During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-Like Kinases (TLKs). Here, we identify TLK phosphorylation sites by mass spectrometry and ...
ORGANISM(S): Homo sapiens (Human) 
2014-03-06 | PXD000686 | Pride
Asf1b Thermolysin Asf1a Phosphopeptide 
UnknownTousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.
Not available
S-EPMC3977046 | biostudies-literature
UnknownTousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.
Not available
S-EPMC7408502 | biostudies-literature
ProteomicsAutophosphorylation of Tousled-like kinases (TLK1 and TLK2) regulates recruitment to damaged chromatin via PCNA interaction (Phospho-TMT analysis of TLK1)
PhosphoTMT experiment on HEK293T cells transiently transfected with either SFB-TLK1, SFB-TLK2, or siRNAs targeting TLK1, TLK2, or TLK1 and TLK2. Data represents 4 biological replicates.
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD047966 | Pride
Phosphoproteomics Tandem affinity purification Tousled-like kinases Phospho-tmt 
UnknownHuman Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
Not available
S-EPMC152895 | biostudies-literature
UnknownDifferential requirements for Tousled-like kinases 1 and 2 in mammalian development.
Not available
S-EPMC5635214 | biostudies-literature
UnknownAutophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction.
Not available
S-EPMC11071368 | biostudies-literature
UnknownAutophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction.
Not available
S-EPMC11879137 | biostudies-literature
UnknownTousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors.
Not available
S-EPMC6082654 | biostudies-literature
ProteomicsAutophosphorylation of Tousled-like kinases (TLK1 and TLK2) regulates recruitment to damaged chromatin via PCNA interaction (Tandem Affinity Purification coupled to LC-MS/MS of SFB-TLK1 WT and TLK2 WT)
S-protein-2xFLAG-Streptavidin binding peptide (SFB)-tagged TLK1 or SFB-TLK2 were transfected into 4x 15 cm plates of HEK293T cells. Cells were harvested 24 hours after transfection using NETN buffer (150 mM NaCl, 0.5 mM EDTA, 20 mM Tris-HCl pH 8.0, 0.5% NP-40) supplemented with 2 µg/mL aprotinin (Th...
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD047996 | Pride
Tandem affinity purification Tousled-like kinases Lc-ms/ms 
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