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TranscriptomicsTranscriptional response to tetanus vaccination in porcine PBMCs
Three groups of German Landrace piglets were vaccinated with tetanus toxoid. Transcriptome profiles of PBMC were analysed from blood samples taken 0, 2, 4, 8, 24 and 75 hours after a first vaccination and 0, 2, 4, 8, 24 and 75 hours as well as 14 d after a second vaccination on day 14. pair wise com...
ORGANISM(S): Sus scrofa 
2012-12-31 | E-GEOD-38602 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human peripheral blood mononuclear cells following oral cholera vaccination
In this study we performed RNA-seq to identify human transcriptomic signatures associated with antibody responses to an oral cholera vaccine. We isolated total RNA from peripheral blood mononuclear cells of vaccinated volunteers who following two priming oral immunisations, had either strong or no a...
ORGANISM(S): Homo sapiens 
2021-03-23 | E-MTAB-9069 | biostudies-arrayexpress
ProteomicsLipid-Coated Nanoparticles Enable Enhanced Delivery of Bacterial Virulence Factors as a Potent Toxoid Vaccine Platform against Bacterial Infections
Antivirulence vaccination represents a promising strategy for infection prevention, but achieving both safety and efficacy in toxoid vaccine preparation remains a challenge. Cell membrane-based nanotoxoids offer a safe delivery platform for bacterial virulence factors in antivirulence vaccination, b...
ORGANISM(S): Pseudomonas aeruginosa PA103 Bacteria 
2025-05-09 | PXD063625 | Pride
Pore-forming toxin Antivirulence Toxoid vaccine Bacterial infection Liposome 
ProteomicsLipid-Coated Nanoparticles Enable Enhanced Delivery of Bacterial Virulence Factors as a Potent Toxoid Vaccine Platform against Bacterial Infections
Antivirulence vaccination represents a promising strategy for infection prevention, but achieving both safety and efficacy in toxoid vaccine preparation remains a challenge. Cell membrane-based nanotoxoids offer a safe delivery platform for bacterial virulence factors in antivirulence vaccination, b...
ORGANISM(S): Bacteria Staphylococcus aureus (strain USA300) 
2025-05-09 | PXD063683 | Pride
Pore-forming toxin Antivirulence Toxoid vaccine Bacterial infection Liposome 
TranscriptomicsTranscriptional response to tetanus toxoid in pigs with divergent humoral and lean growth performance
In vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) during the immune response to tetanus vaccination Comparisons of high (hiLG) vs. low lean growth (loLG) and high antibody titer (hiAB) vs. low AB (loAB) Expt type: Mixed model including repeated...
ORGANISM(S): Sus scrofa 
2013-12-31 | E-GEOD-47845 | biostudies-arrayexpress
ProteomicsHelpful dirt: Why diphtheria toxoid vaccines may also protect against non-toxigenic Corynebacterium diphtheriae strains
Diphtheria toxoid vaccines are among the oldest and safest vaccines known. The basic principle of production is the inactivation of purified diphtheria toxin by formaldehyde cross-linking, which converts the potentially fatal toxin in a completely harmless protein aggregate, which is still immunogen...
ORGANISM(S): Corynebacterium diphtheriae NCTC 13129 Clostridium tetani E88 
2019-04-17 | PXD009289 | Pride
Proteomics Corynebacterium ulcerans Mass spectrometry Corynebacteria Exoproteome Vaccination Secretome 
ProteomicsProteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae
Introduced for mass immunization in the 1920s, vaccines against diphtheria are among the oldest and safest vaccines known. The basic principle of their production is the inactivation of purified diphtheria toxin by formaldehyde cross-linking, which converts the potentially fatal toxin in a completel...
ORGANISM(S): Corynebacterium diphtheriae NCTC 13129 Clostridium tetani E88 
2019-04-18 | PXD012806 | Pride
Proteomics Mass spectrometry Coryebacteria Exoproteome Vaccination Secretome 
GenomicsS. aureus LukAB toxoid design
Design of a stabilized and broadly neutralizing LukAB toxoid, RARPR-33, as a candidate Staphylococcus aureus vaccine antigen
PRJEB98728 | ENA
UnknownPost-licensure safety surveillance study of routine use of tetanus toxoid, reduced diphtheria toxoid and 5-component acellular pertussis vaccine.
Not available
S-EPMC5137522 | biostudies-literature
TranscriptomicsMF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I independent mechanism of action
Analysis of whole mouse muscle and inguinal lymph node gene expression signature induced after 6h by in-vivo intramuscularly administration of MF59, alum, CpG, resiquimod (R848), Pam3CSK4 and DMSO and PBS controls. Analysis of splenocyte gene expression signature induced by the same treatments after...
ORGANISM(S): Mus musculus 
2012-02-22 | E-MTAB-942 | biostudies-arrayexpress
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