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ProteomicsThe OGT TPR Interactome defined by BioID
BioID performed in HeLa cells for the TPR domain of The O-GlcNAc Transferase and eGFP (negative control). Used to determine TPR interactors and the TPR interactome in HeLa cells. Three biological replicates were performed, with each replicate having an experimental (TPR-BirA*) and negative (eGFP-Bir...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-24 | MSV000085626 | MassIVE
GenomicsTPR Knockdown Frac-Seq
TPR Knockdown Frac-Seq
PRJNA559187 | ENA
GenomicsZC3HC1 has functions distinct from TPR and is dispensable for TPR localization to the nuclear basket
ZC3HC1 has functions distinct from TPR and is dispensable for TPR localization to the nuclear basket
PRJNA1209204 | ENA
GenomicsNascent RNA-seq of human AID-NeonGreen-Tpr tagged DLD-1 cells after loss of Tpr nucleoporin
Nascent RNA-seq of human AID-NeonGreen-Tpr tagged DLD-1 cells after loss of Tpr nucleoporin
PRJNA630447 | ENA
GenomicsTotal RNA-seq of siRNA-mediated WTAP and TPR knockdown
Total RNA-seq of siRNA-mediated WTAP and TPR knockdown
PRJNA541857 | ENA
ProteomicsDissecting OGT’s TPR Domain to Identify Determinants of Cellular Function LC-MS/MS
OGT’s tetratricopeptide(TPR) domain is important in substrate recognition, but there is little information on how changing the TPR domain impacts its cellular functions. Here, we investigate how altering OGT’s TPR domain impacts cell growth after the endogenous enzyme is deleted. We find that disrup...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-06 | PXD052018 | Pride
Ogt Tpr Fibroblast Mef 
ProteomicsHDX-MS of CHIP wt and K30A mutant
HDX-MS was used to establish that conformational-inhibition-signals extended from the TPR-domain to the U-box of CHIP. This underscores inter-domain allosteric regulation of CHIP by the core molecular chaperones. Defining the chaperone-associated TPR-domain of CHIP as a manager of inter-domain commu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-30 | MSV000079205 | MassIVE
TranscriptomicsNascent RNA-seq of human AID-NeonGreen-Tpr tagged DLD-1 cells after loss of Tpr nucleoporin
We used SLAM-seq approach to define a contribution of RNA synthesis into RNA abundance changes after Tpr loss. Basket nucleoporin Tpr was AID-tagged and depleted through Auxin Induced Degradation system. Loss of Tpr led to rapid changes in rates of RNA synthesis. The majority of transcripts were dow...
ORGANISM(S): Homo sapiens 
2020-06-15 | GSE149890 | GEO
GenomicsGene expression profile of Baf3 cells overexpressing TPR-FGFR1 fusion gene
Gene expression profile of Baf3 cells overexpressing TPR-FGFR1 fusion gene
PRJNA1137402 | ENA
TranscriptomicsZC3HC1 has functions distinct from TPR and is dispensable for TPR localization to the nuclear basket
Background: The nuclear basket is a ‘fishtrap’-like structure on the nucleoplasmic face of the nuclear pore complex which has been implicated in diverse functions including RNA export, heterochromatin organisation, and mitosis. Recently, a novel component of the nuclear basket, ZC3HC1, has been desc...
ORGANISM(S): Homo sapiens 
2025-02-18 | GSE286436 | GEO
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