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ProteomicsThe OGT TPR Interactome defined by BioID
BioID performed in HeLa cells for the TPR domain of The O-GlcNAc Transferase and eGFP (negative control). Used to determine TPR interactors and the TPR interactome in HeLa cells. Three biological replicates were performed, with each replicate having an experimental (TPR-BirA*) and negative (eGFP-Bir...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-24 | MSV000085626 | MassIVE
ProteomicsHDX-MS of CHIP wt and K30A mutant
HDX-MS was used to establish that conformational-inhibition-signals extended from the TPR-domain to the U-box of CHIP. This underscores inter-domain allosteric regulation of CHIP by the core molecular chaperones. Defining the chaperone-associated TPR-domain of CHIP as a manager of inter-domain commu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-30 | MSV000079205 | MassIVE
ProteomicsDissecting OGT’s TPR Domain to Identify Determinants of Cellular Function LC-MS/MS
OGT’s tetratricopeptide(TPR) domain is important in substrate recognition, but there is little information on how changing the TPR domain impacts its cellular functions. Here, we investigate how altering OGT’s TPR domain impacts cell growth after the endogenous enzyme is deleted. We find that disrup...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-06 | PXD052018 | Pride
Ogt Tpr Fibroblast Mef 
ProteomicsTruncation of the TPR domain of OGT alters substrate and glycosite selection
Nucleocytoplasmic O-linked N-acetylglucosamine (O-GlcNAc) is an essential post-translational modification that is installed to thousands of protein substrates by O-GlcNAc transferase (OGT). Substrate selection by OGT and its isoforms is primarily mediated by the tetratricopeptide repeat (TPR) domain...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD028141 | Pride
Ogt Glycoproteomics Tetratricopeptide repeats (tprs) O-glcnac 
UnknownChaperone ligand-discrimination by the TPR-domain protein Tah1.
Not available
S-EPMC2865030 | biostudies-literature
UnknownDissecting OGT's TPR domain to identify determinants of cellular function.
Not available
S-EPMC11145291 | biostudies-literature
UnknownTruncation of the TPR domain of OGT alters substrate and glycosite selection.
Not available
S-EPMC9647473 | biostudies-literature
UnknownA novel TPR-BEN domain interaction mediates PICH-BEND3 association.
Not available
S-EPMC5737856 | biostudies-literature
UnknownSpatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus.
Not available
S-EPMC12282931 | biostudies-literature
UnknownStructural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
Not available
S-EPMC5642895 | biostudies-literature
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