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TranscriptomicsRNA-seq to investigate gene expression profiles in tumor infiltrating CD8+ T cells with TPX2-overexpression
CD8+ T cells were isolated from fresh human HCC tissues, then treated with lentivirus for TPX2 over-expression or control
ORGANISM(S): Homo sapiens 
2024-02-15 | E-MTAB-10040 | biostudies-arrayexpress
GenomicsTPX2-mediated autophagy maintains cancer stemness in LUAD
TPX2-mediated autophagy maintains cancer stemness in LUAD
PRJNA1471262 | ENA
TranscriptomicsTPX2-mediated autophagy maintains cancer stemness in LUAD
Targeting protein for Xklp2 (TPX2) is a mitotic regulator frequently overexpressed in lung adenocarcinoma (LUAD), while its role in cancer stemness and autophagy remains incompletely understood. In this study, integrative bioinformatic analyses based on TCGA and GTEx datasets revealed that TPX2 over...
ORGANISM(S): Homo sapiens 
2026-05-28 | GSE333531 | GEO
ProteomicsPARP1 proximity proteomics reveals interaction partners at stressed replication forks
PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in response to different types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient breast, ovarian, and prostate cancer. Loss of DNA replication fork protection is proposed as one mechanism that contributes to ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-11 | PXD037154 | Pride
Parp1 Proximity proteomics Ipond Olaparib Adp-ribosylation Tpx2 Replication stress 
GenomicsRNA-seq to investigate gene expression profiles in tumor infiltrating CD8+ T cells with TPX2-overexpression
RNA-seq to investigate gene expression profiles in tumor infiltrating CD8+ T cells with TPX2-overexpression
PRJEB42677 | ENA
GenomicsTPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem Cells
TPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem Cells
PRJNA704811 | ENA
GenomicsTPX2 drives cell cycle progression and impairs immune cell communication in lung cancer based on multi-omics evidence
TPX2 drives cell cycle progression and impairs immune cell communication in lung cancer based on multi-omics evidence
PRJNA1470491 | ENA
UnknownStructural insight into TPX2-stimulated microtubule assembly.
Not available
S-EPMC5679754 | biostudies-literature
TranscriptomicsTPX2 drives cell cycle progression and impairs immune cell communication in lung cancer based on multi-omics evidence
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Despite significant advancements in diagnosis and treatment, its mortality rate persists at alarmingly high levels. TPX2, a critical cell cycle regulatory protein, has been reported to exhibit aberrant ...
ORGANISM(S): Homo sapiens 
2026-08-31 | GSE333209 | GEO
UnknownPhase separation of TPX2 enhances and spatially coordinates microtubule nucleation.
Not available
S-EPMC6959270 | biostudies-literature
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