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ProteomicsChlamydia trachomatis effector Tri1 interacts with TRAF7 to displace native TRAF7 interactors
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections in the US and preventable blindness worldwide. This obligate intracellular pathogen replicates within a membrane-bound inclusion, but how it acquires nutrients from the host while avoiding detection by the innate...
ORGANISM(S): Homo sapiens (Human) Chlamydia trachomatis 
2024-05-05 | PXD049432 | Pride
Chlamydia trachomatis Apms 
ProteomicsMutations in TRAF7 drive meningioma development by dysregulating proteostasis of the RAS-like GTPases
Meningiomas are the most common primary brain tumors, where complete surgical resection is often challenging giving rise to recurrence. Mutations of the E3 ubiquitin ligase TRAF7 are found in one-fourth of meningioma patients and typically co-occur with mutations in either KLF4, AKT1, or PI3KCA. By ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-19 | PXD021188 | Pride
Meningioma Cancer Multi-omics Actin cytoskeleton Ras pathway Semaphorin pathway Proteostasis 
ProteomicsTRAF7 determines circadian period through ubiquitination and degradation of DBP
D-site binding protein, DBP, is a clock-controlled transcription factor and drives daily rhythms of physiological processes through the regulation of an array of genes harboring a DNA binding motif, D-box. DBP protein levels show a circadian oscillation with an extremely robust peak/trough ratio, bu...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-28 | PXD051884 | Pride
Traf7 Ubiquitination Protein degradation Circadian clock Dbp 
GenomicsTRAF7 is an essential regulator of vascular integrity
TRAF7 is an essential regulator of vascular integrity
PRJNA955312 | ENA
TranscriptomicsGenomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO.
We report genomic analysis of 300 meningiomas, the most common primary brain tumors, leading to the discovery of mutations in TRAF7, a proapoptotic E3 ubiquitin ligase, in nearly one-fourth of all meningiomas. Mutations in TRAF7 commonly occurred with a recurrent mutation (K409Q) in KLF4, a transcri...
ORGANISM(S): Homo sapiens 
2014-05-29 | E-GEOD-58037 | biostudies-arrayexpress
TranscriptomicsTRAF7 is an essential regulator of vascular integrity
Targeted deletion of TRAF7 revealed that it is a crucial part of shear stress-responsive MEKK3-MEK5-ERK5 signaling pathway induced in endothelial cells by blood flow. Similarly, to Mekk3-, Mek5- or Erk5-deficient mice, Traf7-deficient embryos died in utero around midgestation due to impaired endothe...
ORGANISM(S): Mus musculus 
2023-06-01 | GSE229698 | GEO
GenomicsGene expression data from HEK293T cells stably expressing human TRAF7 wildtype or G536S mutant isoforms
Gene expression data from HEK293T cells stably expressing human TRAF7 wildtype or G536S mutant isoforms
PRJNA560939 | ENA
UnknownTRAF7 determines circadian period through ubiquitination and degradation of DBP.
Not available
S-EPMC11461874 | biostudies-literature
UnknownPleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease.
Not available
S-EPMC10120005 | biostudies-literature
UnknownTRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation.
Not available
S-EPMC1266438 | biostudies-literature
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