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UnknownInfantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant.
Not available
S-EPMC5219941 | biostudies-literature
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
ProteomicsThe velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt
Velvet domain proteins coordinate developmental processes and secondary metabolism in fungi. In this study, we characterized the role of all four velvet proteins in the life cycle of the plant pathogenic fungus Verticillium dahliae. From other fungi, the formation of different homo-and heterodimers ...
ORGANISM(S): Verticillium dahliae JR2 
2021-02-23 | PXD021861 | Pride
Velvet domain Verticillium dahliae Velvet proteins Plant pathogen 
ProteomicsAnalysis of reconstituted tripartite complex supports avidity-based recruitment of Hsp70 by substrate bound J-domain protein
Hsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis d...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2024-02-19 | PXD044739 | Pride
Hsc20 Hsp70 atpase cycle Substrate delivery Ssq1 Molecular chaperones 
UnknownHigh Systemic Disease Risk and Therapeutic Delays in Plaque Psoriasis: A Retrospective Analysis of Apremilast Use in the British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR).
Not available
S-EPMC11971085 | biostudies-literature
ProteomicsSpatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for responding and elicit a coordinated response to stimuli. Mass spectrometry (MS)-based proteomics in combination with subcellular fractionation can provide comprehensive maps of spa...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-18 | PXD023690 | Pride
Dia Spatio-temporal dynamics Proteomics Phosphoproteomics 
UnknownSex-specific effects of a high fat diet on aortic inflammation and dysfunction.
Not available
S-EPMC10703842 | biostudies-literature
ProteomicsHSP27 Functional Switch Drives Castration-Resistant Prostate Cancer via mTOR Pathway Activation, Highlighting Promising Combination Therapies to Restore Treatment Sensitivity
Heat shock protein 27 (HSP27) is a multifunctional protein that plays pivotal roles in prostate cancer (PC) progression to a castration-resistant state, known as CRPC. In this study, we identified and analyzed HSP27-protein interaction maps across various prostatic cell models recapitulating differe...
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD056858 | Pride
Ap-ms Lc-msms Castration resistant prostate cancer (crpc) Hsp27 Mtor pathway Interactome 
UnknownImpact of the WHO "best buys" for alcohol policy on consumption and health in the Baltic countries and Poland 2000-2020.
Not available
S-EPMC10636269 | biostudies-literature
ProteomicsHIV-1 Nef Reprograms Neuronal Lipid Rafts to Drive Neuroinflammation and Neurodegeneration in HIV-associated Neurocognitive Impairment
HIV-associated neurological disorders (HAND) remain a common co-morbidity of HIV infection. HIV protein Nef has been shown to increase the abundance of neuronal lipid rafts - cholesterol- and sphingolipid-rich membrane microdomains implicated in neurodegeneration and neuroinflammation. Here, we inve...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD065713 | Pride
Nef Exosomes. Neurons Hiv Hiv-associated neurological disorder Lipid rafts Neurodegeneration 
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