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TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells
Reversible protein phosphorylation is one of the most important posttranslational modifications (PTMs) due to its vital role in cellular functions and signaling pathways. Protein phosphorylation is also known to be involved in the regulation of apoptosis. Previously, we have performed a SILAC-based ...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD004415 | Pride
: apoptosis Mass spectrometry Phosphorylation Cisplatin Phosphoproteomics 
ProteomicsTCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors in vivo
CTNNB1/ ꞵ-catenin is mutated in 3.3% of solid cancers, with several recurrent gain-of-function mutations occurring early during cancer formation. This includes the shared driver mutation CTNNB1S37F, estimated to occur in >7000 new cancer cases in 2024 in the US. However, to offer attractive immunoth...
ORGANISM(S): Homo sapiens (Human) 
2025-07-15 | PXD054276 | Pride
Β-catenin In vivo T cells Immunotherapy 
TranscriptomicsGene expression profiling in mature OT-II TCR transgenic CD4 SP thymocytes, either Jmjd3- and Utx-deficient or -sufficient.
The biological functions of histone demethylases Jmjd3 and Utx remain poorly understood. We assessed such functions in developing T cells, using conditional (CD4-Cre-mediated) gene disruption, by inactivating Kdm6a and Kdm6b, respectively encoding Utx and Jmjd3, in immature CD4+CD8+ thymocytes. We c...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-70363 | biostudies-arrayexpress
ProteomicsEarly NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T...
ORGANISM(S): Homo sapiens (Human) 
2025-05-21 | PXD061694 | Pride
Dengue Cd4+ t-cells Cd8+ t-cells Co-inhibitory receptors Cytotoxic cells Severe dengue biomarkers Nk-cells Type-i ifn 
UnknownChanges in Markers of T-Cell Senescence and Exhaustion With Atazanavir-, Raltegravir-, and Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.
Not available
S-EPMC4978379 | biostudies-literature
UnknownTraN: A novel repressor of an Enterococcus conjugative type IV secretion system.
Not available
S-EPMC6158623 | biostudies-literature
UnknownEffect of TraN key residues involved in DNA binding on pIP501 transfer rates in <i>Enterococcus faecalis</i>.
Not available
S-EPMC10877727 | biostudies-literature
UnknownSystematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma.
Not available
S-EPMC7210316 | biostudies-literature
UnknownSTOMPing Out Hormone-Sensitive Metastases With Local Therapies in Prostate Cancer.
Not available
S-EPMC9250283 | biostudies-literature
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