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ProteomicsStructure of Saccharomyces cerevisiae Mediator-RNA polymerase II pre-initiation complex for divergent transcription
This study has determined structure of transcription initiation complexes including a DNA-bound activator, RNA polymerase II (Pol II), and Mediator on a divergent promoter GAL80/SUT719 using a combination of cryo-EM and XL-MS analyses. Our cryo-EM single-particle analysis reveals a dimeric form of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD036149 | Pride
Enhancer Divergent transcription Transcription Mediator Uas Initiation Activator Rna polymerase ii 
TranscriptomicsThe kinase TNIK is an essential activator of Wnt target genes
Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/ß-catenin activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/ß-catenin transcriptional progra...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17623 | biostudies-arrayexpress
ProteomicsHomeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3
Host defense by the innate immune system requires the establishment of antimicrobial states allowing cells to cope with microorganisms before the onset of the adaptive immune response. Interferons (IFN) are of vital importance in the establishment of cell-autonomous antimicrobial immunity. Speed is...
ORGANISM(S): Mus Musculus 
PXD013251 | panorama
UnknownTranscription co-activator SAYP mediates the action of STAT activator.
Not available
S-EPMC3315317 | biostudies-literature
ProteomicsChaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes
Transcription initiation involves the coordinated activities of large multimeric complexes that are organized into functional modules. Little is known about the mechanisms and pathways that govern their assembly from individual components. We report here several principles governing the assembly of ...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2019-10-02 | PXD013256 | Pride
Multimeric complex Transcription Chaperone Chromatin 
TranscriptomicsEH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA development, and for the efficient di...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-45831 | biostudies-arrayexpress
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
TranscriptomicsMechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis
Data from clinical studies, cell culture, and animal models implicate the urokinase (uPA)/Plasminogen (Plg) system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/Plg stimulate these diseases are not yet defined. We used genetically modified, atherosc...
ORGANISM(S): Mus musculus 
2011-05-03 | E-GEOD-29028 | biostudies-arrayexpress
ProteomicsAllosteric activation mechanism of DriD, a WYL-domain containing transcription regulator
This project aims to understand the ssDNA-mediated allosteric activation mechanism of DriD, a novel Caulobacter crescentus transcription activator. Using LC-MS/MS, the major proteolytic cleavage site within DriD was identified, providing insight into its solvent accessible regions.
ORGANISM(S): Caulobacter vibrioides 
2025-04-14 | PXD062430 | Pride
Lc-ms/ms Drid Caulobacter crescentus Transcription activator 
ProteomicsSigma E of Streptomyces coelicolor can function both as a direct activator or repressor of transcription
Sigma factors are key components of the bacterial transcriptional apparatus that are essential for promoter recognition and transcription initiation. These factors are considered as positive regulators of gene expression. Here, we reveal the opposite, inhibitory role of these proteins. We used a com...
ORGANISM(S): Streptomyces coelicolor 
2024-01-26 | PXD041877 | Pride
Sigmae Bacterial transcriptional apparatus 
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