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TranscriptomicsRegulation of Transcription Termination by Glucosylated Hydroxymethyluracil, Base J, in L. major and T. brucei
Base J, β-D-glucosyl-hydroxymethyluracil, is an epigenetic modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. J is enriched at sites involved in RNA Polymerase (RNAP) II initiation and termination. We have previously demonstrated a role of J in regulating...
ORGANISM(S): Trypanosoma brucei 
2015-05-18 | E-GEOD-57621 | biostudies-arrayexpress
TranscriptomicsA conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing [sRNA-seq]
Co-transcriptional RNA processing and surveillance factors mediate heterochromatin formation in fission yeast. In addition to RNAi, RNA elimination machinery including MTREC (Mtl1-Red1 core) and the exosome are involved in facultative heterochromatin assembly, however, the exact mechanisms remain un...
ORGANISM(S): Schizosaccharomyces pombe 
2016-01-05 | E-GEOD-74739 | biostudies-arrayexpress
ProteomicsPP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA pol II transcription termination
The restrictor, ZC3H4/WDR82, terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitate with PP1 phosphatase and its nuclear targeting subunit, PNUTS, which binds to WDR82. AlphaFold predicts a complex of PP1/...
ORGANISM(S): Homo sapiens (Human) 
2025-04-06 | PXD061598 | Pride
Pp1 phosphatase Ctd dephosphorylation Zc3h4 Pol ii ctd ser5 phosphorylation Restrictor Wdr82 Transcription termination Transcription elongation 
UnknownRho-dependent transcription termination: a revisionist view.
Not available
S-EPMC8632121 | biostudies-literature
GenomicsAKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage.
Purpose: In this study, we show that DNA damage-activated AKT phosphorylates threonine 45 of core histone H3 (H3-T45) Result: By genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) analysis, H3-T45 phosphorylation was distributed throughout DNA damage-responsive gene loci, particularly i...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-67699 | biostudies-arrayexpress
TranscriptomicsRho directs widespread termination of intragenic and stable RNA transcription
The transcription termination factor Rho is a global regulator of RNA polymerase (RNAP). Although individual Rho-dependent terminators have been studied extensively, less is known about the sites of RNAP regulation by Rho on a genome-wide scale. Using chromatin immunoprecipitation and microarrays (...
ORGANISM(S): Escherichia coli 
2010-05-18 | E-GEOD-16562 | biostudies-arrayexpress
TranscriptomicsRoad-block transcription termination by Reb1p enforces transcription boundaries
Widely transcribed and compact genomes face the major challenge of coping with frequent overlapping or concurrent transcription events. Efficient and timely transcription termination is crucial to control pervasive transcription. In yeast, RNA polymerase II (RNAPII) termination mainly occurs via two...
ORGANISM(S): Saccharomyces cerevisiae 
2014-12-05 | E-MTAB-2241 | biostudies-arrayexpress
TranscriptomicsBase J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination
Base J and H3.V promote RNA Polymerase (RNAP) II termination within polycistronic gene clusters in the kinetoplastid species Trypanosoma brucei. Although base J has been shown to promote RNAP II termination in the related kinetoplastid species Leishmania major and Leishmania tarentolae, the role of ...
ORGANISM(S): Leishmania major 
2016-07-20 | E-GEOD-77632 | biostudies-arrayexpress
UnknownDNA-directed termination of RNA polymerase II transcription.
Not available
S-EPMC7615648 | biostudies-literature
GenomicsTranscription and export complex (THO/TREX) coordinates transcription termination in Arabidopsis
Transcription and export complex (THO/TREX) coordinates transcription termination in Arabidopsis
PRJNA529202 | ENA
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