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ProteomicsThe Super Elongation Complex Drives Transcriptional Addiction in MYCN-amplified Neuroblastoma
MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification. Yet how MYCN coordinates transcription elongation to meet productive transcriptional amplification and which elongation machinery represents MYCN-dr...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039332 | Pride
Mycn Neuroblastoma Super elongation complex (sec) Transcription elongation Abt-199 
GenomicsCK2 regulates transcriptional elongation
CK2 binds to actively transcribed regions in the genome and regulates transcriptional elongation. Identification of genome-wide binding sites of CK2?, and examination of the effect of Pol II binding upon CK2 inhibition in LNCaP cells
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-58607 | biostudies-arrayexpress
Transcriptomics4sUDRB-seq: measuring transcription elongation and initiation genomewide
A new method to measure elongation and intitiation rates Reversal inhibition of transcription with DRB and tagging newly transcribed RNA with 4-thiouridine (4sU)
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-57116 | biostudies-arrayexpress
TranscriptomicsThe little elongation complex (LEC) regulates small nuclear RNA transcription
The Eleven-nineteen Lysine-rich Leukemia (ELL)-containing Super Elongation Complex (SEC) containing P-TEFb is a key regulator in the expression of HOX genes in Mixed Lineage Leukemia (MLL)-based leukemia. We have identified an SEC-like complex in Drosophila, as well as a distinct ELL-containing comp...
ORGANISM(S): Drosophila melanogaster 
2011-12-22 | E-GEOD-32120 | biostudies-arrayexpress
TranscriptomicsA Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory
LSD1n regulates transcriptional elongation by removing H4K20 methylation. Identification of genome-wide binding sites of LSD1, and examination of the histone modifications upon LSD1n deletion in primary cortical neurons
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-63271 | biostudies-arrayexpress
ProteomicsYLR455 affinity purification - An H3K36me3 binding PWWP protein targets the NuA3 acetyltransferase complex to coordinate transcriptional elongation at coding regions
These studies define a new form of the NuA3 complex that associates with H3K36me3 to effect transcriptional elongation.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-08-14 | PXD001156 | Pride
Epigenetics Pwwp domain Histone methylation Gene regulation Nua3 Transcription elongation Histone acetylation 
TranscriptomicsComparison of the transcriptomes of tfIIs vs Col-0
Testing the consequences of the absence of the transcript elongation factor TFIIS on the transcriptome in Arabidopsis. Keywords: Comparison of mutant and wildtype Four replicate RNA extractions were performed of each genotype using independent pools of plants. Samples were hybridized in two dye-swap...
ORGANISM(S): Arabidopsis thaliana 
2010-04-03 | E-GEOD-10663 | biostudies-arrayexpress
TranscriptomicsThe SEC family of RNA Polymerase II elongation factors: gene target specificity and transcriptional output
The elongation stage of transcription is a highly regulated in metazoan. We previously purified the AFF1/AFF4-containing Super Elongation Complex (SEC) as a major regulator of development and cancer pathogenesis. Here, we report the biochemical isolation of SEC-like 2 (SEC-L2) and SEC-like 3 (SEC-L3...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-34097 | biostudies-arrayexpress
TranscriptomicsA triple-HLH/bHLH Cascade Controls Cell Elongation Downstream of Multiple Hormonal and Environmental Signaling Pathways
The environmental and endogenous signals, light, temperature, brassinosteroid (BR), and gibberellin (GA), regulate cell elongation largely by controlling the expression of the PRE family helix-Loop-helix (HLH) factors, which promote cell elongation by interacting antagonistically with another HLH fa...
ORGANISM(S): Arabidopsis thaliana 
2015-01-01 | E-GEOD-41766 | biostudies-arrayexpress
TranscriptomicsMitotic Transcriptional Clearance of Actively Engaged Pol II Through Transcriptional Elongation Control
Chromatin is highly condensed and transcriptionally repressed during mitosis. Although it is established that some general transcription factors are inactivated by phosphorylation at mitosis, many details of mitotic transcriptional repression and its underlying mechanisms are largely unknown. Here, ...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-71848 | biostudies-arrayexpress
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