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ProteomicsAltered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia
Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in hi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD010924 | Pride
Chronic lymphocytic leukemia Translational fidelity Ribosomal decoding center Cll Rps15 Proteostasis 
GenomicsGenome-wide screening reveals metabolic regulation of translational fidelity by cyclic AMP
Genome-wide screening reveals metabolic regulation of translational fidelity by cyclic AMP
PRJNA947930 | ENA
GenomicsA coding sequence-embedded principle governs translational reading frame fidelity
A coding sequence-embedded principle governs translational reading frame fidelity
PRJNA318051 | ENA
GenomicsRole of eEF2 diphthamide modification in translational fidelity
Role of eEF2 diphthamide modification in translational fidelity
PRJNA735209 | ENA
ProteomicsCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
We describe circadian clock-dependent changes in ribosome composition in Neurospora crassa depending on cell type, stress, or developmental state. Mass spectrometry of ribosomes isolated at different circadian times identified six ribosomal proteins and one ribosome-associated protein with clock-con...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) 
2024-10-15 | MSV000096101 | MassIVE
TranscriptomicsGenome-wide screening reveals metabolic regulation of translational fidelity by cyclic AMP
Translational quality control is critical for maintaining the accuracy of protein synthesis in all domains of life. Mutations in aminoacyl-tRNA synthetases and the ribosome are known to affect translational fidelity and alter fitness, viability, stress responses, neuron function, and life span. In t...
ORGANISM(S): Escherichia coli BW25113 
2023-03-28 | GSE228051 | GEO
ProteomicsHuman TRMT2A methylates different components of the translation machinery and contributes to translation fidelity
Methyl-5-uridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme of m5U conversion at tRNA position 54. However, its RNA binding specificity and functional role in the cell are not well unders...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD036538 | Pride
Rna biogenesis Translational fidelity Methyl-5-uridine (m5u) Rna methylation Trna methyltransferase 2 homolog a (htrmt2a) Interactome Mammalia 
UnknownOptimal translational fidelity is critical for Salmonella virulence and host interactions.
Not available
S-EPMC6547416 | biostudies-literature
GenomicsStructures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes: Is rRNA Fragmentation Linked to Translational Fidelity?
Structures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes: Is rRNA Fragmentation Linked to Translational Fidelity?
PRJNA1313923 | ENA
UnknownClinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity.
Not available
S-EPMC8406222 | biostudies-literature
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