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MetabolomicsProteomic analysis of osteocyte line (MLO-Y4) with knockout of cystic fibrosis transmembrane conductance regulator (CFTR) or chloride deprivation treatment

Mass spectrometry–based proteomic analysis of an osteocyte line, MLO-Y4, was conducted to profile global protein expression changes under two experimental settings, 1) CRISPR-Cas9-based knockout of CFTR versus wild-type; 2) Cl- deprivation versus normal extracellular medium.

2026-03-27 | MTBLS14165 | MetaboLights
TranscriptomicsDisrupted interaction of transmembrane prostatic acid phosphatase and snapin will lead to prostate cancer
Disrupted interaction of transmembrane prostatic acid phosphatase and snapin will lead to prostate cancer
ORGANISM(S): Mus musculus 
2013-09-12 | E-MTAB-1191 | biostudies-arrayexpress
ProteomicsSurfactants regulate the function and structure of transmembrane protein of Bacillus cereus——promote transmembrane transport of polycyclic aromatic hydrocarbons (PAHs)
Polycyclic Aromatic Hydrocarbons (PAHs) can be degraded by its highly efficient degrading bacteria, Bacillus cereus. The transmembrane transport is very important in the process of PAHs adsorption, uptake, transmembrane transport, and degradation by Bacillus cereus. Surfactants are the key substance...
ORGANISM(S): Bacillus Cereus Atcc 14579 
2020-03-21 | PXD018137 |
TranscriptomicsTranscription profiling of mouse expressing non-cleavable transmembrane mutant form of murine TNFalpha, or treated with soluble TNFalpha (20ng/ml) for 4 hours to investigate divergent and convergent effects on gene expression and function in acute versus chronic endothelial activation
Activation of the vascular endothelium with cytokines such as TNF is widely used to study the role of the vasculature in proinflammatory disease. To gain insight into mechanisms of prolonged vascular endothelial activation we compared changes in gene expression induced by continuous activation in st...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-4518 | biostudies-arrayexpress
ProteomicsMultiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression
Our study provides an enabling technology and rich data resources to expand the understanding of transmembrane proteome organization and dynamics in the brain as well as accelerate the discovery of potential therapeutic targets for depression treatment.
ORGANISM(S): Mus Musculus 
2021-07-26 | PXD027559 |
GenomicsTransmembrane TNF-TNFR2 axis promotes generation of human T cell precursors.
Transmembrane TNF-TNFR2 axis promotes generation of human T cell precursors.
PRJNA870102 | ENA
ProteomicsFormation of ER-lumenal intermediates during export of Plasmodium proteins containing transmembrane-like hydrophobic sequences
REX3RQLSE:Pf332:C-S11:DSLE is exported and is diffusely localised in the red blood cell cytoplasm (Fig 3A). Mutation of the PEXEL sequence (REX3AQLSE:Pf332:C-S11:DSLE), results in the protein being retained in the parasite (Fig 3C), and addition of a C-terminal SDEL sequence (REX3RQLSE:Pf332:C-S11:S...
ORGANISM(S): Plasmodium falciparum 
2023-03-28 | PXD036904 | Pride
Plasmodium Proteomics Lc-ms/ms 
ProteomicsMolecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins
Protein trafficking requires coat complexes that couple recognition of sorting motifs in transmembrane cargos with biogenesis of transport carriers. The mechanisms of cargo transport through the endosomal network are poorly understood. Here, we identify a sorting motif for endosomal recycling of car...
ORGANISM(S): Homo sapiens (Human) 
2021-05-28 | PXD014927 | Pride
Snx-bars Endosomes Transmembrane proteins Endocytosis Ci-mpr 
ProteomicsComparative proteomic analysis for a polytopic transmembrane protein in Acidovorax citrulli
- Identification of proteins whose expression was affected by a polytopic transmembrane protein in Acidovorax citrulli str. KACC17005 - Shotgun proteomic analysis was used - Two strains were used with three biological replicates (total 6 samples). YM_WT: the wild-type strain. YM_7G: a polytopic tra...
ORGANISM(S): Paracidovorax 
2026-07-14 | PXD077370 | Pride
Acidovorax citrulli Polytopic transmembrane protein Lc-ms/ms 
GenomicsERBB2/HER2 transmembrane and juxtamembrane domain mutations in cancer
In this study, we identified several recurrent activating HER2 somatic mutations in transmembrane and juxtamembrane domain in multiple cancers and demonstrate that patients carryingthese mutations are candidates for anti-HER2 therapy. We have also identified a germline mutation in HER2 transmembrane...
EGAS00001003213 | EGA
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