Treisman Richard R

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Transcriptomics (2)
Proteomics (2)

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Mus musculus (2)
Alphavirus (2)
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Betaherpesvirinae (2)
Brassica oleracea var. oleracea (2)
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EFO:0001352 (2)
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biostudies-arrayexpress (2)
pride (2)

Tissue

Brain (1)
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Neuron (1)

Technology Type

Mass Spectrometry (2)
Shotgun proteomics (2)

Publication Date

2020 (2)
2015 (1)
2014 (1)

Study type

RNA-seq of coding RNA (2)

Release Date

2015 (1)
2014 (1)

Lab affiliation

Director of Research Head, Signalling and Transcription Group The Francis Crick Institute 1 Midland Road, London NW11AT, UK (1)
Director of Research Head, Signalling and Transcription Group The Francis Crick Institute, 1 Midland Road, London, UK (1)

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Phactr1/PP1 phosphatase substrates in mouse NIH3T3 fibroblasts

It was previously shown that expression of an activated Phactr1 mutant (Phactr1XXX) that constitutively forms the Phactr1/PP1 phosphatase holoenzyme, induces F-actin rearrangements in NIH3T3 fibroblasts. Expression of the Phactr1 PP1-binding domain (C-terminal) alone is also sufficient to induce suc...

ORGANISM(S): Mus musculus (Mouse)

2020-10-28 | PXD019977 | Pride

Phactr1/PP1 phosphatase substrates in mouse primary neurons

Neurons express Phactr1 at high level (Allen et al., 2004), and Phactr1 mutations are associated with morphological and functional developmental defects in cortical neurons (Hamada et al., 2018). To identify targets of the Phactr1/PP1 phosphatase holoenzyme, we cultured hippocampal and cortical neur...

ORGANISM(S): Mus musculus (Mouse)

2020-10-28 | PXD019882 | Pride

Neurons Phosphatase Mouse Phactr1

MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development

Chemokine signaling is important for the seeding of different sites by hematopoietic stem cells during development. Serum Response Factor (SRF) controls multiple genes governing adhesion and migration, mainly by recruiting members of the Myocardin-Related Transcription Factor (MRTF) family of G-acti...

ORGANISM(S): Mus musculus

2015-03-04 | E-GEOD-63820 | biostudies-arrayexpress

Definition of the fibroblast SRF-mediated immediate-early transcriptional response

To control transcription, SRF recruits signal-regulated co-activators, the Ternary Complex Factors (TCFs) and the Myocardin-related Transcription Factors (MRTFs), which compete for a common site on its DNA-binding domain. The TCFs - SAP-1, Elk-1 and Net - are Ets proteins that link SRF activity to R...