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ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
GenomicsTrim27 confers myeloid hematopoiesis competitiveness by upregulating myeloid master genes
Trim27 confers myeloid hematopoiesis competitiveness by upregulating myeloid master genes
PRJNA471853 | ENA
GenomicsDynamic acetylation/deacetylation dictates TRIM27 nuclear-cytoplasmic localization for cancer progression
Dynamic acetylation/deacetylation dictates TRIM27 nuclear-cytoplasmic localization for cancer progression
PRJNA1449926 | ENA
GenomicsDynamic acetylation/deacetylation dictates TRIM27 nuclear-cytoplasmic localization for cancer progression [CUT&Tag]
Dynamic acetylation/deacetylation dictates TRIM27 nuclear-cytoplasmic localization for cancer progression [CUT&Tag]
PRJNA1455621 | ENA
GenomicsTRIM27 mediates protective immunity against tuberculosis by activating host autophagy flux
Infectious diseases, such as Mycobacterium tuberculosis (Mtb)-caused tuberculosis (TB), remain a global health threat exacerbated by increasing drug resistance. Host-directed therapy (HDT) is a complementing strategy for infection treatment through targeting host immune mechanisms. However, the limi...
ORGANISM(S): Homo sapiens 
2024-07-03 | GSE237039 | GEO
TranscriptomicsDynamic acetylation/deacetylation dictates TRIM27 nuclear-cytoplasmic localization for cancer progression
Cancer invasion and metastasis are governed by intricate molecular mechanisms. We demonstrate that TRIM27, an E3 ubiquitin ligase, plays dichotomous roles in cancer depending on its subcellular localization, which is controlled by acetylation/deacetylation at K297 independent of its ligase activity....
ORGANISM(S): Homo sapiens 
2026-04-27 | GSE327188 | GEO
TranscriptomicsTrim27 confers myeloid hematopoiesis competitiveness by upregulating myeloid master genes
RNAseq were performed to analyze the transcriptomic differences between Trim27-overexpressing MP and empty vector control MP
ORGANISM(S): Mus musculus 
2018-06-01 | GSE114579 | GEO
UnknownTRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal.
Not available
S-EPMC9887071 | biostudies-literature
GenomicsDynamic acetylation/deacetylation dictates TRIM27 nuclear-cytoplasmic localization for cancer progression [CUT&Tag II]
Dynamic acetylation/deacetylation dictates TRIM27 nuclear-cytoplasmic localization for cancer progression [CUT&Tag II]
PRJNA1456556 | ENA
UnknownTRIM27 promotes the development of esophagus cancer via regulating PTEN/AKT signaling pathway.
Not available
S-EPMC6839104 | biostudies-literature
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