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ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
GenomicsNon-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis
Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here we find that the non-canonical PRC1.1 complex, as identified by mass spectrometry-based proteomics, is critically important for human leukemic stem cells. D...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-54580 | biostudies-arrayexpress
ProteomicsSustained PRC1.1 activity preserves gene repression independent of PRC2.2 and suppresses leukemic cell differentiation
Loss-of-function mutations in BCOR, subunit of the non-canonical Polycomb Repressive Complex 1.1 (PRC1.1), are frequently observed in acute myeloid leukemia (AML) and associate with adverse risk, but underlying mechanisms driving leukemogenesis remain elusive. Here, we find that BCOR is a bridging f...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD065157 | Pride
Human Exploris480 
UnknownDOT1L provides transcriptional memory through PRC1.1 antagonism.
Not available
S-EPMC12904788 | biostudies-literature
UnknownTargeted disruption of PRC1.1 complex enhances bone remodeling.
Not available
S-EPMC12062457 | biostudies-literature
UnknownKDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1.
Not available
S-EPMC5088048 | biostudies-literature
UnknownThe USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia.
Not available
S-EPMC8169803 | biostudies-literature
GenomicsDOT1L provides transcriptional memory through PRC1.1 antagonism [ChIP-Seq]
DOT1L provides transcriptional memory through PRC1.1 antagonism [ChIP-Seq]
PRJNA1083204 | ENA
UnknownBCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes.
Not available
S-EPMC9414116 | biostudies-literature
GenomicsDOT1L provides transcriptional memory through PRC1.1 antagonism [RNA-seq]
DOT1L provides transcriptional memory through PRC1.1 antagonism [RNA-seq]
PRJNA1081797 | ENA
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