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ProteomicsInteractome of POU5F1B detected by LC-MSMS in HT29 and LS1034 CRC cells overexpressing POU5F1B-HA
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor, we found that expression of the hominid-restricted retrogene POU5F1B...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD028034 | Pride
Human Lc-msms Pou5f1b Ht29 Ls1034 Overexpression Colorectal cancer 
ProteomicsSILAC & LC-MSMS in total cell extracts or in the secretome of sh-scramble vs. shRNA3 & shRNA5 LS1034 cells
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor, we found that expression of the hominid-restricted retrogene POU5F1B...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD028036 | Pride
Human Knock-down Lc-msms Pou5f1b Ls1034 Silac Colorectal cancer 
ProteomicsSILAC & LC-MSMS in total cell extracts or in the secretome of POU5F1B- vs. GFP-overexpressing SW480 cells
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor, we found that expression of the hominid-restricted retrogene POU5F1B...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD028035 | Pride
Human Lc-msms Pou5f1b Silac Overexpression Sw480 Colorectal cancer 
TranscriptomicsRNA-seq and expression profile of WT and ZFP57 KO ES cells
RNA-seq and expression profile of WT and ZFP57 KO ES cells RNA was extracted from both cell lines, PolyA RNA were extracted and RNA-seq was performed
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-31182 | biostudies-arrayexpress
TranscriptomicsMinocycline is an inhibitor of the TNF-alpha induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 breast cancer cells
Using a Cre-LoxP-based cell fusion assay we able to demonstrate that the fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 breast cancer cells was induced by TNF-alpha both under normoxic and hypoxic conditions. To investigate the impact of TNF-alpha on the gene expressio...
ORGANISM(S): Homo sapiens 
2018-04-23 | E-MTAB-6084 | biostudies-arrayexpress
GenomicsChIP-Seq of HA tagged ZFP57 and KAP1 in mouse ES cells
We have performed ChIP seq analysis to obtain the positions of KAP1 and ZFP57 binding sites in mouse ES cells. By comparing the two lists, we were able to find bona fide sites. ChIP-Seq of HA tagged ZFP57 and KAP1 in mouse ES cells
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-31181 | biostudies-arrayexpress
TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
TranscriptomicsKRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy [Seq]
A multilayered transcription regulatory system is unveiled, where protein- and RNA-based repressors are super-imposed in combinatorial fashion to govern the timely triggering of an essential step of erythropoiesis Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO (or KD) ce...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-44061 | biostudies-arrayexpress
TranscriptomicsRNA-seq of naive and primed ES cells (NHSM)
Here we propose a set of molecular criteria for evaluating the naive human pluripotent state. We show by RNA-seq that transcription of transposable elements provides a sensitive measure of the concordance between pluripotent stem cells and early human development. RNA-seq of 3 naive ES samples in NH...
ORGANISM(S): Homo sapiens 
2016-08-16 | E-GEOD-85689 | biostudies-arrayexpress
UnknownSARS-CoV-2 S Omicron Spike B.1.1.529
Not available
EMPIAR-10947 | biostudies-other
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