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ProteomicsParallel genetic excisions of the cardiac troponin I N-terminal extension in tachycardic mammals
A study of cardiac troponin I evolution in mammals with high heart rates, including shrews, moles, and bats. With genomic, mRNA and protein level analyses we showed repeated loss of the N-terminal extension. Here, liquid chromatography with tandem mass spectrometry was used to verify cardiac troponi...
ORGANISM(S): Galemys pyrenaicus Blarina brevicauda 
2024-07-19 | PXD048600 | Pride
Troponin Sarcomere Shrew Mole 
ProteomicsTruncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways
We employed isobaric labeled peptides to do bottom-up proteomics to quantify both non-enriched total peptides and enriched phospho-peptides obtained from hearts of control mice expressing wild-type cardiac troponin I and transgenic mice expressing the truncated N-terminal cardiac troponin I.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-03-15 | MSV000087049 | MassIVE
TranscriptomicsTranscription profiling of zebrafish embryos following cardiac troponin T2 knockdown
We examined the transcriptional effect of preventing cardiac contraction in zebrafish embryos which can be deprived of circulation without experiencing hypoxia since the fish obtain sufficient oxygen via diffusion. Morpholino antisense knockdown of cardiac troponin T2 (tnnt2) prevented cardiac contr...
ORGANISM(S): Danio rerio 
2009-07-05 | E-GEOD-16740 | biostudies-arrayexpress
ProteomicsHuman cTnT fragmentation in serum
Cardiac troponin T (cTnT) is a highly cardiospecific protein commonly used in the diagnosis of acute myocardial infarction (AMI), but is subject to proteolytic degradation upon its release in the circulation. In this study, a targeted mass spectrometry assay was developed to detect peptides which ar...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080749 | MassIVE
TranscriptomicsTranscription profiling of wild type wild type ,TnT transgenic for human Troponin ( non mutated), T10 transgenic for human truncated Troponin
WT wild type ,TnT transgenic for human Troponin ( non mutated), T10 transgenic for human truncated Troponin
ORGANISM(S): Rattus norvegicus 
2003-05-22 | E-RZPD-6 | biostudies-arrayexpress
ProteomicsMass spectrometric ITEM-TWO analyses of interactions between human cardiac Troponin T (hcTnT) peptides and the M7 or the M11.7 antiTnT antibodies.
Molecular characterization of antibodies M7, and M11.7, as well as the antiTNF alpha antibody in addition to the synthetic peptides P11-P17 and P21-P32. The M7 and M11.7 anti-human cardiac Troponin T (antihcTnT) antibodies from Roche Diagnostics Deutschland GmbH (Mannheim, Germany) and the antiTNF a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD058812 | Pride
Item-two Troponin t Offline nanoesi-ms 
TranscriptomicsTranscription profiling of wild type and delK210 cTnT knock-in mouse heart to study dilated cardiomyopathy
Changes in the gene expression in the heart of knock-in mouse model of dilated cardiomyopathy caused by delK210 mutation in cardiac troponin T.
ORGANISM(S): Mus musculus 
2008-09-04 | E-MEXP-1340 | biostudies-arrayexpress
ProteomicsAberrant troponin post-translational modifications with TNNT1 mutations
TNNT1 mutations are associated with congenital myopathies. Here, we aimed to investigate whether troponin T post-translational modifications would be affected by the mutations. For that, we used muscle biopsy specimens from patients with TNNT1 mutations and controls. We then defined the nature and l...
ORGANISM(S): Homo sapiens (Human) 
2025-01-08 | PXD054504 | Pride
Troponin Genetic disorder Skeletal muscle 
ProteomicsTroponin T mutations associated with HCM
Proteomic comparison of heart muscle wild type and transgenic troponin T mice (R278C and 179N mutations).
ORGANISM(S): Mus Musculus 
2016-02-27 | MSV000079538 | MassIVE
ProteomicsIntact Transition Epitope Mapping - Force differences between Original and Unusual Residues (ITEM-FOUR)
Human cardiac Troponin I epitope peptides were incubated with monoclonal anti-cardiac Troponin I antibody. Immune complexes were subjected to nano electrospray mass spectrometry in order to determine apparent binding energies and dissociation constants of immune complex dissociation reactions in the...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD038365 | Pride
Item-four Troponin i Offline nanoesi-ms 
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