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TranscriptomicsThe transcriptome of TRPV1-positive sensory neurons revealed by subgroup-elimination transcriptomics
We developed an approach to rapidly eliminate the subgroup of sensory neurons expressing the heat-gated cation channel TRPV1 from dissociated rat sensory ganglia using agonist treatment followed by density centrifugation. To identify transcripts predomintly expressed in TRPV1-positive neurons, we co...
ORGANISM(S): Rattus norvegicus 
2015-05-12 | E-GEOD-59727 | biostudies-arrayexpress
TranscriptomicsAlternative splicing of the TRPV1 gene underlies infrared sensation in vampire bats
Vampire bats and snakes have taken thermosensation to the extreme by developing specialized systems for detecting infrared radiation. As such, these creatures provide a window into the molecular and genetic mechanisms underlying evolutionary tuning of thermoreceptors in a species or cell type specif...
ORGANISM(S): Desmodus rotundus 
2011-08-04 | E-GEOD-28243 | biostudies-arrayexpress
ProteomicsPeptidomics-guided identification of TRPV1-targeting peptides from Apis mellifera venom and macrophage proteomics
Bee venom has been traditionally used in the treatment of inflammatory disorders and is known to contain diverse bioactive peptide components. In this study, we systematically characterized the Apis mellifera venom peptidome and investigated peptides enriched under TRPV1 pull-down conditions with po...
ORGANISM(S): Mus musculus (Mouse) Apis mellifera (Honeybee) 
2026-04-17 | PXD075103 | Pride
Peptidomics Proteomics Macrophage Inflammation Apis mellifera venom Pull-down Trpv1 
GenomicsTRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
PRJNA838996 | ENA
ProteomicsSUMOylation-Induced Membrane Localization of TRPV1 Suppresses Proliferation and Migration in Gastric Cancer Cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050942 |
ProteomicsThe role and mechanism of TRPV1 SUMOylation in inhibiting the proliferation and migration of gastric cancer cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Mus Musculus 
2024-03-25 | PXD050941 |
GenomicsMus musculus strain:TRPV1 tomato
Mus musculus strain:TRPV1 tomato Transcriptome or Gene expression
PRJNA308243 | ENA
GenomicsTRPV1-Independent and Sex-Specific Capsaicin Signatures in Drosophila
TRPV1-Independent and Sex-Specific Capsaicin Signatures in Drosophila
PRJNA1308527 | ENA
GenomicsThe transcriptome of TRPV1-positive sensory neurons revealed by subgroup-elimination transcriptomics
The transcriptome of TRPV1-positive sensory neurons revealed by subgroup-elimination transcriptomics
PRJEB6878 | ENA
TranscriptomicsTRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
To examine the functional significance of TRPV1 SUMOylation in vivo, we created a TRPV1K823R KI transgenic mouse line.We thus performed gene expression profiling analysis using data obtained from RNA-seq of the trigeminal ganglion of TRPV1K823R and control mouse models . Our analyses unveiled a role...
ORGANISM(S): Mus musculus 
2022-06-14 | GSE203197 | GEO
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