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ProteomicsTRPV6 essentially contributes to Ca2+ influx in endometrial epithelial cells and female mouse fecundity
The Ca2+-selective transient receptor potential vanilloid 6 (TRPV6) channel plays a fundamental role in the mouse female and male reproductive system. In mouse endometrium the TRPV6 protein is highly expressed in epithelial cells (MEECs). Using Ca2+ imaging and patch clamp analysis we found that TRP...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD060418 | Pride
Meec Fecundity Endometrium Trpv6 Mesc 
ProteomicsThe intracellular localization and the ionic permeation of TRPV6 triggers chronic pancreatitis, skeletal dysplasia and is connected to mucolipidosis type II
Heterozygous TRPV6 mutations, which reduce significantly the Ca2+-permeability of the channel, lead to chronic pancreatitis and, if both TRPV6-alleles are affected, to skeletal dysplasia with neonatal transient hyperparathyroidism (TNHP) of newborns. We show that TRPV6 channels are localized in intr...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD065752 | Pride
Transient receptor potential I-cell disease Trpv6 Mucolipidosis type ii Skeletal dysplasia Calcium channel Gnptab Chronic pancreatitis Mannose-6-phosphate 
ProteomicsThe intracellular localization and the ionic permeation of TRPV6 triggers chronic pancreatitis, skeletal dysplasia and is connected to mucolipidosis type II (data part II)
Heterozygous TRPV6 mutations, which reduce significantly the Ca2+-permeability of the channel, lead to chronic pancreatitis and, if both TRPV6-alleles are affected, to skeletal dysplasia with neonatal transient hyperparathyroidism (TNHP) of newborns. We show that TRPV6 channels are localized in intr...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD065789 | Pride
Transient receptor potential I-cell disease Trpv6 Mucolipidosis type ii Skeletal dysplasia Calcium channel Gnptab Chronic pancreatitis Mannose-6-phosphate 
GenomicsRNA-seq of human prostate cancer cell line PC-3M trpv6 knockout versus wild type and PC3M-Luc-C6 wild type versus trpv6 overexpression.
RNA-seq of human prostate cancer cell line PC-3M trpv6 knockout versus wild type and PC3M-Luc-C6 wild type versus trpv6 overexpression.
PRJNA964459 | ENA
TranscriptomicsRNA-seq of human prostate cancer cell line PC-3M trpv6 knockout versus wild type and PC3M-Luc-C6 wild type versus trpv6 overexpression.
TRPV6 is a membrane protein, a member of the transient receptor potential (TRP) ion channel family. The TRPV6 cation channel is highly selective for Ca2+, with PCa/PNa values greater than 100, playing a crucial role in calcium homeostasis in various cell types. Previous transcriptome analysis indica...
ORGANISM(S): Homo sapiens 
2023-07-24 | GSE231352 | GEO
UnknownTRPV6 Regulation by Cis-22a and Cholesterol.
Not available
S-EPMC9221249 | biostudies-literature
UnknownAutoinhibition of TRPV6 Channel and Regulation by PIP2.
Not available
S-EPMC7452202 | biostudies-literature
UnknownPhotoswitchable Inhibitor of the Calcium Channel TRPV6.
Not available
S-EPMC6746075 | biostudies-literature
UnknownOpening of the human epithelial calcium channel TRPV6.
Not available
S-EPMC5854407 | biostudies-literature
UnknownTRPV6 alleles do not influence prostate cancer progression.
Not available
S-EPMC2774862 | biostudies-literature
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