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ProteomicsTryptase regulation of joint lubrication and inflammation in osteoarthritis
Proteoglycan 4 (PRG4) is an extracellular matrix protein that maintains homeostasis through its boundary lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have been associated with joint inflammatory diseases, including osteoarthritis (OA). We found that mast cell...
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD037040 | Pride
Proteoglycan-4 Tryptase Proteases Single-cell rna-seq Lubricin Osteoarthritis Lubrication Proteomics N-terminomics 
GenomicsMast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
PRJNA1327197 | ENA
GenomicsExpression data from HUVECs treated with tryptase or PAR-2 peptide agonist (SLIGKV-NH2)
Expression data from HUVECs treated with tryptase or PAR-2 peptide agonist (SLIGKV-NH2)
PRJNA564998 | ENA
TranscriptomicsMast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
Mast cells accumulate in breast cancer, but there is only limited knowledge of how they impact on breast cancer growth. Here we show that tryptase, a major compound stored in mast cell secretory granules, has profound effects on breast cancer cell morphology and growth, the latter by a combination o...
ORGANISM(S): Homo sapiens 
2025-12-03 | GSE307724 | GEO
GenomicsMast cell tryptase induces nuclear remodeling in breast cancer cells and has a negative impact on breast cancer cell growth
Mast cells are known to accumulate in breast cancer, but there is only limited knowledge of how they may impact on breast cancer growth. Tryptase is one of the major compounds stored in the mast cell secretory granules, and here we investigated whether tryptase can have an influence on breast cancer...
ORGANISM(S): Homo sapiens 
2025-09-17 | GSE308338 | GEO
UnknownMast Cell-Derived Tryptase in Geographic Atrophy.
Not available
S-EPMC5699534 | biostudies-literature
UnknownMast Cell Tryptase Potentiates Neutrophil Extracellular Trap Formation.
Not available
S-EPMC9485958 | biostudies-literature
UnknownTryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice.
Not available
S-EPMC3615996 | biostudies-literature
UnknownSevere food allergy reactions are associated with α-tryptase.
Not available
S-EPMC10592152 | biostudies-literature
UnknownDose-dependent inactivation of airway tryptase with a novel dissociating anti-tryptase antibody (MTPS9579A) in healthy participants: A randomized trial.
Not available
S-EPMC8841439 | biostudies-literature
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