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TranscriptomicsGene Expression data from Pdx-1CreAPC+/LP53L/L pancreatic ductal adenocarcinoma (PDAC) cells versus Pdx-1CreP53L/L normal pancreatic ductal cells
Analysis of primary PDAC cells established from Pdx-1CreAPCL/+p53L/L and Pdx-1Crep53L/L mice. APC haploinsufficiency combined with P53 loss in the pancreas drives MCN progression in mice. Results provide insight into molecular mechanisms invloved in the MCN formation of Pdx-1Cre APCL/+P53L/L mice....
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-61894 | biostudies-arrayexpress
UnknownS-phase arrest after vincristine treatment may promote hepatitis B virus replication.
Not available
S-EPMC4316092 | biostudies-literature
TranscriptomicsRegulatory RNA Apela Is a Component of a Negative Feedback Loop Regulating p53-Mediated Apoptosis in Embryonic Stem Cells (III)
The goal is to identify RNAs that bind to Hnrnpl (hnRNP L) using RNA immunoprecipitation (RIP) assay. p53+/+ mES cells and p53-/- mES cells were untreated or treated with 0.5 uM Adriamycin for 8 hours. RNA immunoprecipitation was performed using Hnrnpl antibody (Bethyl, Cat#: A311-423A). Total RNA w...
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-62378 | biostudies-arrayexpress
GenomicsEpigenetic marks and factors binding to chromatin in mouse embryonic stem cells
The goal is to profile several histone modifications and hnRNP L in untreated or Adriamycin-treated mouse embryonic stem cells. Fifty million of R1E mES cells were untreated or treated with 0.5 uM Adriamycin for 8 hours. Fixed cells were subject to ChIP-seq assay.
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-62864 | biostudies-arrayexpress
TranscriptomicsRegulatory RNA Apela Is a Component of a Negative Feedback Loop Regulating p53-Mediated Apoptosis in Embryonic Stem Cells (II)
The goal is to identify regulatory RNAs that regulate the p53 signaling pathway in embryonic stem (ES) cells. p53+/+ mES cells and p53-/- mES cells were untreated or treated with 0.5 uM Adriamycin for 8 hours. Total RNA was extracted and subject to RNAseq.
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-60843 | biostudies-arrayexpress
UnknownStable QTLs for Plant Height on Chromosome A09 Identified From Two Mapping Populations in Peanut (Arachis hypogaea L.).
Not available
S-EPMC5982159 | biostudies-literature
TranscriptomicsRegulatory RNA Apela Is a Component of a Negative Feedback Loop Regulating p53-Mediated Apoptosis in Embryonic Stem Cells (I)
p53-repressed transcripts have recently been shown to play important roles in various biological processes, such as stem cell differentiation and cancer. We identified a transcript named Apela that is repressed by p53 and highly expressed in mouse ES cells. To see which transcripts are affected by A...
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-54355 | biostudies-arrayexpress
Unknown"Superwobbling" and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code.
Not available
S-EPMC8879553 | biostudies-literature
UnknownSelf-assembled, hemin-functionalized peptide nanotubes: an innovative strategy for detecting glutathione and glucose molecules with peroxidase-like activity.
Not available
S-EPMC9899300 | biostudies-literature
Unknown<i>Lactobacillus acidophilus</i> ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.
Not available
S-EPMC11364073 | biostudies-literature
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