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MetabolomicsDelayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle

Exercise is fundamental to healthy aging, yet the degree to which it mitigates age-related molecular changes and how varying physical fitness levels influence the molecular response to exercise with age remain unclear. To address this, we performed transcriptomics, lipidomics, and metabolomics on...

2026-04-09 | MTBLS12824 | MetaboLights
ProteomicsSnap-heated freeze-free preservation and processing of the urine proteome
New method for urine proteome preservation and processing based on thermal stabilization and FASP digestion. Four urine proteomes were preserved during 48 h and 6 months using (i) the classic freeze preservation at -20 °C, (ii) snap-heated freeze-free preservation at laboratory temperature (20 °C) a...
ORGANISM(S): Homo sapiens (Human) 
2020-01-10 | PXD012880 | Pride
Stabilizor-based technology Lc-msms Human urine Fasp Proteome preservation 
TranscriptomicsThe Extracellular RNA Quality Control (exRNAQC) study: Small RNA sequencing of blood collection tube study (exRNAQC013)
To evaluate the impact of blood collection tubes on extracellular RNA (exRNA) sequencing, 10 different blood collection tubes were compared by applying Small RNA sequencing (Illumina) to exRNA from human healthy donor plasma or serum. Three time spans between blood draw and downstream processing wer...
ORGANISM(S): Homo sapiens 
2021-06-10 | E-MTAB-10506 | biostudies-arrayexpress
TranscriptomicsThe Extracellular RNA Quality Control (exRNAQC) study: RNA Exome sequencing of blood collection tube study (exRNAQC005)
To evaluate the impact of blood collection tubes on extracellular RNA (exRNA) sequencing, 10 different blood collection tubes were compared by applying RNA Exome sequencing (Illumina) to exRNA from human healthy donor plasma or serum. Three time spans between blood draw and downstream processing wer...
ORGANISM(S): Homo sapiens 
2021-06-10 | E-MTAB-10507 | biostudies-arrayexpress
TranscriptomicsSingle-cell analysis of human fetal bone marrow
Toal 13 patient samples (Iliac or pyramidal cancellous) were collected with lung cancer who were pathologically diagnosed in Dazhou Central Hospital from June 2020 to January 2021. Patients were monitored by a professional orthopaedic surgeon in the interventional room prior to collecting the sample...
ORGANISM(S): Homo sapiens 
2022-11-27 | E-MTAB-11560 | biostudies-arrayexpress
TranscriptomicsNOTCH and WNT pathways regulate stemness and differentiation in human fallopian tube long term organoid culture
We report the establishment of a stable 3D in vitro organoid culture procedure from human fallopian tube samples and confirming experimentally the existence of adult stem cells in this epithelial tissue. Long term growth and the differentiation of the organoids depend on the interplay between the pa...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-60919 | biostudies-arrayexpress
ProteomicsMetaproteomic analysis of paired fresh, frozen and swab-collected/preservation medium-stored feces from four healthy human subjects
Metaproteomic analysis of paired fresh, frozen and swab-collected/preservation medium-stored feces from four healthy human subjects
ORGANISM(S): Homo sapiens (Human) human gut metagenome 
2025-10-16 | PXD047278 | Pride
Stool Gut microbiota Swabs Preservation medium Metaproteomics 
ProteomicsPre-Analytical Framework for Routine Clinical Use of Liquid Biopsies: Combining EVs and cfDNA
Liquid biopsies hold significant potential for the non-invasive diagnostics of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extracellular vesicles (EVs) as validated biomarkers is hindered by substan...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD062837 | Pride
Extracellular vesicles Liquid biopsy Cfdna Human plasma Tube preservation Isolation protocol Pre-analytics Translation 
TranscriptomicsNOTCH and WNT pathways regulate stemness and differentiation in human fallopian tube long term organoid culture
We report the establishment of a stable 3D in vitro organoid culture procedure from human fallopian tube samples and confirming experimentally the existence of adult stem cells in this epithelial tissue. Long term growth and the differentiation of the organoids depend on the interplay between the pa...
ORGANISM(S): Homo sapiens 
2015-01-01 | GSE60919 | GEO
GenomicsGenome-wide study of the effect of blood collection tubes on the cell-free DNA methylome
Background The methylation pattern of cfDNA, isolated from liquid biopsies, is gaining substantial interest for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood collection tube and time delay between blood draw and plasma preparation on bisulfite-based cfDNA methyl...
EGAS00001004271 | EGA
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