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ProteomicsTTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity 2/2
The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-13 | PXD043138 | Pride
Phf5a and ttc33 form a vertebrate-specific novel complex coined ttc33-associated network (tan) which together with ccdc97 regulate levels of mrnas that mediate neurotransmitter release Wdr61 
TranscriptomicsCtk1 + CTD mutants
Transcription termination in Saccharomyces cerevisiae can be performed by at least two distinct pathways and is directed by the phosphorylation status of the carboxy-terminal domain (CTD) of RNA polymerase II (Pol II). Late termination of mRNAs is performed by the CPF/CF complex and requires CTD-Ser...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-22 | E-GEOD-40254 | biostudies-arrayexpress
ProteomicsTTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity 1/2
The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD043098 | Pride
Wdr61 (ski8) Ung Ttc33 Pp2a Sf3ab Ski complex Paf complex Neurotransmitter Ccdc97 Ppp2r2a (b55a) Cga Hormone Phf5a 
ProteomicsComparative mass spectrometry reveals a novel TTC33-associated network core (TANC) complex with functions in DNA damage response
TTC33 is a 30 kDa human uncharacterized tetratricopeptide repeat protein. Here, we employed label-free mass spectrometry analysis to identify the proteins interactors. The TTC33-associated network (TAN) is composed of WDR61, PHF5A, which together with TTC33 form a trimeric core complex (TANC), that ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD059336 | Pride
Ttc33 Dna repair Wdr61 Pafc Ung dna glycosylase Skic Phf5a 
ProteomicsComparative mass spectrometry reveals a novel TTC33-associated network core (TANC) complex with functions in DNA damage response
TTC33 is a 30 kDa human uncharacterized tetratricopeptide repeat protein. Here, we employed label-free mass spectrometry analysis to identify the proteins interactors. The TTC33-associated network (TAN) is composed of WDR61, PHF5A, which together with TTC33 form a trimeric core complex (TANC), that ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD059337 | Pride
Ttc33 Dna repair Wdr61 Pafc Ung dna glycosylase Skic Phf5a 
ProteomicsComparative mass spectrometry reveals a novel TTC33-associated network core (TANC) complex with functions in DNA damage response
TTC33 is a 30 kDa human uncharacterized tetratricopeptide repeat protein. Here, we employed label-free mass spectrometry analysis to identify the proteins interactors. The TTC33-associated network (TAN) is composed of WDR61, PHF5A, which together with TTC33 form a trimeric core complex (TANC), that ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD066861 | Pride
Ttc33 Dna repair Wdr61 Pafc Ung dna glycosylase Skic Phf5a 
UnknownModeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay
Not available
S-SCDT-10_1038-S44318-024-00258-3 | biostudies-other
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