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ProteomicsTTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity 2/2
The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-13 | PXD043138 | Pride
Phf5a and ttc33 form a vertebrate-specific novel complex coined ttc33-associated network (tan) which together with ccdc97 regulate levels of mrnas that mediate neurotransmitter release Wdr61 
ProteomicsDetermination of Trunk Neural Crest Cell Fate and Susceptibility to Splicing Perturbation by the DLC1-SF3B1-PHF5A splicing complex
How the ubiquitously expressed splicing factors specifically regulate neural crest (NC) development and enhance their vulnerability to splicing perturbations remain poorly understood. Here, we show that NC-specific DLC1, partnering with SF3B1-PHF5A splicing complex, are crucial for determining avian...
ORGANISM(S): Gallus Gallus 
2025-06-09 | PXD064804 |
ProteomicsTargeting an RNA polymerase II-associated PHF5A protein subcomplex with a KMT2A-WDR5 inhibitor impairs self-renewal and tumorigenicity of pancreatic cancer stem cells
Pancreatic cancer (PC) remains one of the most aggressive and life-threatening malignancies known for its notorious resistance to chemotherapy. This is increasingly ascribed to the subpopulation of undifferentiated cells, known as pancreatic cancer stem cells (PCSCs), which are evolutionary fitter t...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD038378 | Pride
Epigenetics Cancer stem cells Pancreatic cancer Phf5a complex Kmt2a-wdr5 inhibitor 
GenomicsTranscriptome-wide identification of transcripts regulated by PHF5A in colorectal cancer cells
Transcriptome-wide identification of transcripts regulated by PHF5A in colorectal cancer cells
PRJNA746339 | ENA
UnknownPHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2.
Not available
S-EPMC8605294 | biostudies-literature
UnknownSplicing control by PHF5A is crucial for melanoma cell survival.
Not available
S-EPMC11839196 | biostudies-literature
ProteomicsTTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity 1/2
The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD043098 | Pride
Wdr61 (ski8) Ung Ttc33 Pp2a Sf3ab Ski complex Paf complex Neurotransmitter Ccdc97 Ppp2r2a (b55a) Cga Hormone Phf5a 
GenomicsPHF5A coordinates p300 for epigenetic regulation of lipogenesis to promote hepatocellular carcinoma progression
PHF5A coordinates p300 for epigenetic regulation of lipogenesis to promote hepatocellular carcinoma progression
PRJNA702753 | ENA
UnknownPHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS.
Not available
S-EPMC9817416 | biostudies-literature
TranscriptomicsTranscriptome-wide identification of transcripts regulated by PHF5A in colorectal cancer cells
Dysregulated alternative splicing (AS) plays critical roles in driving cancer progression, and the underlying mechanisms remain largely unknown. Here we demonstrated that PHF5A, a component of U2 snRNPs, was frequently upregulated in colorectal cancer (CRC) samples and associated with poor prognosis...
ORGANISM(S): Homo sapiens 
2021-07-16 | GSE180042 | GEO
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