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ProteomicsA clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. The determination of TM-interconnectivity in individual tumors has been challenging and the impact on patient survival unresolved. Here, a connectivity signature from si...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD044001 | Pride
Gene expression signature Glioblastoma Connectivity Tumor microtubes Single-cell rna-sequencing 
UnknownGlioblastoma tumor microtubes and brain fatty acid-binding protein: Path to directional infiltration.
Not available
S-EPMC12916726 | biostudies-literature
UnknownTumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner.
Not available
S-EPMC7353147 | biostudies-literature
UnknownTumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma.
Not available
S-EPMC7881116 | biostudies-literature
ProteomicsProteomics of tumor and serum samples from isocitrate dehydrogenase-wildtype glioblastoma patients: is the detoxification of reactive oxygen species associated with shorter survival?
Proteomics has been little used for the identification of novel prognostic and/or therapeutic markers in isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GB). In this study, we analyzed 50 tumor and 30 serum samples from short- and long-term survivors of IDH-wildtype GB (STS and LTS, respective...
ORGANISM(S): Homo sapiens (Human) 
2024-07-04 | PXD045714 | Pride
Dia-ms  tims-tof-pro  glioblastoma  survival 
TranscriptomicsMorphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections
Glioblastoma is a major unmet clinical need characterized by striking inter- and intra-tumoral heterogeneity and a population of glioblastoma stem cells (GSCs), conferring aggressiveness and therapy resistance. GSCs communicate through a network of tumor-tumor connections (TTCs), including nanotubes...
ORGANISM(S): Homo sapiens 
2024-11-12 | GSE280761 | GEO
GenomicsMorphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections
Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections
PRJNA1180487 | ENA
ProteomicsTargeting tumor-intrinsic neural vulnerabilities of glioblastoma
The neural behavior of glioblastoma, including the formation of tumor microtubes and synaptic circuitry, is increasingly understood to be pivotal for disease manifestation (Osswald et al. 2015; Venkatesh et al. 2015; Weil et al. 2017; Venkataramani et al. 2019; Venkatesh et al. 2019; Alcantara Llagu...
ORGANISM(S): Homo Sapiens 
PXD037015 | panorama
UnknownMorphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections.
Not available
S-EPMC11599137 | biostudies-literature
ProteomicsEvaluation of Tumor Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer
Tumor infiltrating lymphocytes (TILs) play a significant role in the tumor microenvironment in high-grade serous ovarian cancer (HGSOC). To better understand the interactions and functions of TILs in HGSOC progression, we performed proteogenomic profiling of TILs in 65 tumors collected from 12 HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2024-03-15 | PXD045710 | Pride
Lc-ms Ovarian cancer Hgsoc Tumor infiltrating lymphocytes 
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