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GenomicsRNA sequencing data of differentially treated cancer associated fibroblast, myeloid-derived supression cells, and ICC tumor cells in ICC patient
RNA sequencing data of differentially treated cancer associated fibroblast, myeloid-derived supression cells, and ICC tumor cells in ICC patient
PRJNA666424 | ENA
TranscriptomicsReal-time quantitative PCR analysis of BMI1-silenced human prostate cancer cells
BMI1-silenced Prostate cancer cells exhibited a significant change in the expression of several proliferation-associated genes. These included Cyclin-D1, BCL2, IL and NF-kappaB. An increased expression of p16, p15 and TIMP3 in BMI1-silenced tumor cells was observed List of Selected Genes Modulated b...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-44049 | biostudies-arrayexpress
UnknownRA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.
Not available
S-EPMC6539016 | biostudies-literature
GenomicsEssential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-speci...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-64137 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of BMI1-silenced human prostate cancer cells
BMI1-silenced Prostate cancer cells exhibited a significant change in the expression of several proliferation-associated genes. These included Cyclin-D1, BCL2, IL and NF-kappaB. An increased expression of p16, p15 and TIMP3 in BMI1-silenced tumor cells was observed List of Selected Genes Modulated b...
ORGANISM(S): Homo sapiens 
2013-02-05 | GSE44049 | GEO
UnknownSustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer.
Not available
S-EPMC10150544 | biostudies-literature
TranscriptomicsRNA sequencing data of differentially treated cancer associated fibroblast, myeloid-derived supression cells, and ICC tumor cells in ICC patient
An interactive tumor microenvironment with different stromal cell types is necessary for supporting cancer stemness. Cancers with dense fibrotic stroma such as intrahepatic cholangiocarcinoma (ICC) are often highly aggressive and chemotherapy resistance. Here, we show that cancer associated fibrobla...
ORGANISM(S): Homo sapiens 
2022-01-01 | GSE158755 | GEO
ProteomicsA Covalent PFKL Activator Suppresses Tumor Growth
Glycolysis fuels vital cellular functions and its dysregulation is implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, presents a key vulnerability for developing targeted anticancer agents but remains challen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD078921 | Pride
Pfkl Edc Covalent activator Tumor supression Glycolysis 
GenomicsMYC-mediated immune supression in TNBC
MYC promotes immune-suppression in TNBC via inhibition of IFN signaling
PRJEB43214 | ENA
TranscriptomicsSingle-cell RNA sequencing from PiKP-785 cancer cells under 4 treatment conditions: Kras* On, Kras* 3d off, Kras* 5d off, and Kras* On off on
Single-cell RNA sequencing analysis was performed on primary pancreatic ductal adenocarcinoma derrived cell line from PiKP (P48-Cre; R26-rtTa-IRES-EGFP; tetO-LSL-KrasG12D/+; Trp53L/L) murine tumors. In this study we establish that oncogenic Kras is the predominant driver of T cell paucity and myeloi...
ORGANISM(S): Mus musculus 
2023-07-22 | GSE201887 | GEO
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