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TranscriptomicsCellular Transcriptional Responses to Merkel cell polyomavirus T antigens
Merkel cell polyomavirus (MCV) is clonally integrated in over 80% of Merkel cell carcinomas and mediates tumor development through the expression of viral oncoproteins large T (LT) and small T antigens (sT). Viral integration is associated with signature mutations in the T antigen locus that result ...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-68503 | biostudies-arrayexpress
ProteomicsTumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.
The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells to detect cancer-related antigenic peptides has refocused the need to fully understand the repertoire of peptides being presented to the immune system. Whilst the peptide ligandome prese...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD025345 | Pride
Cancer Extracellular vesicles T-cell epitopes Taa Hla class i ligandome Evs Tumour. Tumour-associated antigens 
UnknownIdentification and analysis of tumour-associated antigens in hepatocellular carcinoma.
Not available
S-EPMC2361901 | biostudies-literature
UnknownThe polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens.
Not available
S-EPMC2360579 | biostudies-literature
ModelsLeon-Triana2021 - Competition between tumour cells and single-target CAR T-cells
This model of the use of chimeric antigen receptor (CAR)-T cell therapy in the treatment of solid tumours is described in the article: "Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept" Odelaisy León-Triana, Antonio...
2024-09-02 | BIOMD0000001013 | BioModels
Immuno-oncology 
ModelsLeon-Triana2021 - Competition between tumour cells and dual-target CAR T-cells
This model of the use of chimeric antigen receptor (CAR)-T cell therapy in the treatment of solid tumours is described in the article: "Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept" Odelaisy León-Triana, Antonio...
2024-09-02 | BIOMD0000001014 | BioModels
Immuno-oncology 
UnknownSmaller size packs a stronger punch - Recent advances in small antibody fragments targeting tumour-associated carbohydrate antigens.
Not available
S-EPMC10240822 | biostudies-literature
ProteomicsAn Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumour Development: Secretomics
Cancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment (TME), serving diverse functions in tumour progression, invasion, matrix remodelling and resistance to therapy. Extensive molecular characterization revealed an increased ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-08 | PXD047038 | Pride
Autophagy Cancer-associated fibroblasts Immune synapse Immunity T regulatory cells Anti-tumour immunity Antigen presentation Secretome 
TranscriptomicsCheckpoint Blockade Cancer Immunotherapy Targets Tumor-Specific Mutant Antigens
Cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and Programmed death-1 (PD-1) are immunoregulatory receptors expressed on T cells that play important roles in suppressing immune responses to cancer. Although monoclonal antibodies that target CTLA-4 or PD-1 stimulate therapeutic anti-tumour T ce...
ORGANISM(S): Mus musculus 
2014-11-07 | GSE62771 | GEO
GenomicsDNGR1 carcinogenesis
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumour immunity
PRJEB100660 | ENA
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