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EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5’ untranslated regions. However, very little is known of their roles in non-malignant cells. Using mouse models to d...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-09 | PXD046710 | Pride
Amyotrophic lateral sclerosis is a clinical syndrome with complex biological determinants, but which in most cases is characterised by TDP-43 pathology. The identification in CSF of a protein signature of TDP-43 network dysfunction would have the potential to inform the identification of new biomark...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD024219 | Pride
A whole genome screen was used to assay every gene of Escherichia coli strain BW25113 to identify genes involved in susceptibility to the monobactam (beta-lactam) antibiotic aztreonam. The methodology has been called TraDIS-Xpress, and is a version of TraDIS or Tn-seq. A transposon mutant library c...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used high-resolution mass spectrometry to quantify the proteome of B cell subsets from the mouse spleen and map the diffe...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-29 | PXD043349 | Pride
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used high-resolution mass spectrometry to quantify the proteome of B cell subsets from the mouse spleen and map the diffe...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-29 | PXD043351 | Pride
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