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Transcriptomics90 min Met4 hyperactivation ChIP-chip
Identification of in vivo binding targets of Met4 and Met32 by conducting chromatin immunoprecipitation studies using genomic tiling arrays (ChIP-on-chip 4X44K whole yeast genome arrays by Agilent) following 90 minutes Met4 hyperactivation.
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-21 | E-MEXP-3302 | biostudies-arrayexpress
ProteomicsNRS1, a nitrogen source-regulated microprotein, confers an alternative mechanism of G1/S transcriptional activation in budding yeast
Commitment to cell division at the end of G1 phase, termed Start in the budding yeast Saccharomyces cerevisiae, is strongly influenced by nutrient availability. To identify newdominant activators of Start that might operate under different nutrient conditions, we screened a genome-wide ORF overexpr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-25 | PXD018681 | Pride
G1/s transcription Start Quantitative microscopy Nutrient limitation Evolution Microprotein Genetic screen Transcription factor Saccharomyces cerevisiae 
ProteomicsImipridones cause cellular toxicity in human cells and bacteria by ectopic activation of the ClpP protease
Ectopic activation of the conserved ClpP protease by chemical activators causes toxicity in bacteria and human cells due to unrestrained proteolysis. The imipridone ONC201 has been ascribed multiple mechanisms of action and is currently in cancer clinical trials. To systematically investigate the ge...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2020-03-26 | PXD016119 | Pride
Imipridones Clpp protease 
TranscriptomicsMet4 hyperactivation timecourse
The met31 single delete and the met32 single delete strains were analyzed for genome-wide transcription at different times following Met4 hyeractivation and compared to cells that contain both Met31 and Met32.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-21 | E-MEXP-3301 | biostudies-arrayexpress
ProteomicsDisruption of splicing, proliferation and stemness via PRMT5 inhibition as a therapeutic strategy for GBM
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein Arginine Methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogonal-acting inhibitors of PRMT5 (GSK591 or LLY-283), ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-03 | PXD021635 | Pride
Cancer Proteomics Glioblastoma Prmt5 inhibition 
TranscriptomicsComparative genomic hybridization of yeast to determine size characteristics of yeast haploid deletion strains separated by elutriation
Determination of size characteristics of pools of yeast haploid deletion strains by elutriation and barcode analysis.
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-15 | E-MEXP-1200 | biostudies-arrayexpress
ProteomicsSzewczyk_InhibitionOfPRMT7_P36_2020
This dataset consists of 16 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition (DDA) mode for the 8 input files and DDA with simultaneous parallel reaction monitoring (targeted masses; 599.33, 604.33, 608.23, 606.33, 407.89, 403.22, 651.3...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-08 | MSV000084773 | MassIVE
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae pGAL1-MKS1, pGAL1-NNK1, and pGAL1-FMP48 overexpression
Analysis of the transcriptional effects of pGAL1-MKS1, pGAL1-NNK1, and pGAL1-FMP48 overexpression. BY4700 gal1::NAT ura3delta0 S. cerevisiae cells carrying a [pGAL1-MKS1-HA, URA3, CEN], [pGAL1-NNK1-HA, URA3, CEN], or [pGAL1-FMP48-HA, URA3, CEN] plasmid, or empty vector BG1805, were grown to early lo...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-25 | E-MEXP-2171 | biostudies-arrayexpress
TranscriptomicsAn in vivo screen identifies compounds that disrupt heterochromatin integrity
Heterochromatin plays a key role in gene repression, maintaining genome integrity and chromosome segregation. Fission yeast, Schizosaccharomyces pombe, utilizes conserved components to direct heterochromatin formation using siRNA generated by RNA interference (RNAi) to guide a histone H3 lysine 9 me...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-17 | E-GEOD-57207 | biostudies-arrayexpress
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