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ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - verification of ubiquitin UBE2R1 (C93K) loading assay
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049050 | Pride
Structural Mimetic Ube2r1 Ubiquitin E2 
UnknownMechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.
Not available
S-EPMC4959314 | biostudies-literature
UnknownA siRNA screening of UBE2 family demonstrated that UBE2R1 had a high repressive effect on HIV Tat protein.
Not available
S-EPMC9578976 | biostudies-literature
OtherRobust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways
The large family of SCF ubiquitin ligases catalyze ubiquitylation by bridging protein substrates and ubiquitin-modifying enzymes. S. cerevisiae SCFs employ a sole, essential enzyme, Cdc34, to build poly-ubiquitin chains required for degradation. However, humans have no less than six chain building e...
ORGANISM(S): Homo sapiens 
2020-01-01 | GSE136175 | GEO
UnknownRSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1.
Not available
S-EPMC5081560 | biostudies-literature
UnknownFBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.
Not available
S-EPMC7657132 | biostudies-literature
UnknownRobust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.
Not available
S-EPMC6975927 | biostudies-literature
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of BRD4 ubiquitination sites
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049043 | Pride
Protac Mz1 Ubiquitin Crl2vhl Brd4 
UnknownMechanism of degrader-targeted protein ubiquitinability.
Not available
S-EPMC11468923 | biostudies-literature
GenomicsRobust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways
Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways
PRJNA561505 | ENA
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