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UnknownUbiquitin Chain Enrichment Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains in Cellulo.
Not available
S-EPMC5541364 | biostudies-literature
UnknownTechnical report: Targeted proteomic analysis reveals enrichment of atypical ubiquitin chains in contractile murine tissues.
Not available
S-EPMC7567960 | biostudies-literature
ProteomicsProtein abundance changes and ubiquitylation targets identified upon inhibition of the proteasome with Syringolin A
The numerous roles of the ubiquitin proteasome system (UPS) in cellular control have triggered interest in the identification of these ubiquitylation targets and their sites of ubiquitylation. For the identification of ubiquitylated proteins we employed affinity enrichment using an ubiquitin binding...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2014-04-15 | PXD000566 | Pride
Ubiquitylation Syringolin a Affinity enrichment Ubiquitin proteasome system Quantitative proteomics 
ProteomicsGlobal ubiquitinome profiling identify Nedd4 as aregulator of Profilin 1 and actin remodeling in neural crest cells
We utilized quantitative analyses of the proteome, transcriptome, and ubiquitinome to study how ubiquitination and NEDD4 control neural crest cell survival and stem-cell-like properties. We report 276 novel NEDD4 targets in neural crest cells and show that loss of NEDD4 leads to a striking global r...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-08 | PXD024103 | Pride
Nedd4 Ubiquitin remnant enrichment Mouse Neural crest 
UnknownCo-expression network analysis and cis-regulatory element enrichment determine putative functions and regulatory mechanisms of grapevine ATL E3 ubiquitin ligases.
Not available
S-EPMC5816651 | biostudies-literature
ProteomicsAnalysis of the ubiquitin-modified proteome identifies novel host determinants of Kaposi’s sarcoma herpesvirus lytic reactivation
Kaposi’s Sarcoma Herpesvirus (KSHV) is the causative agent of Kaposi’s Sarcoma (KS) and isassociated with primary effusion lymphoma (PEL), multicentric Castleman’s disease (MCD) and two inflammatory diseases. KSHV-associated cancers are primarily associated with genes expressed during latency, while...
ORGANISM(S): Homo sapiens (Human) 
2024-11-24 | PXD046571 | Pride
Kaposi’s sarcoma herpesvirus Proteome Ubiquitin 
ProteomicsMapping Ubiquitination Sites in Alzheimer's Disease
Alzheimer’s Disease (AD) is characterized by the deposition of protein aggregates such as neurofibrillary tangles (NFTs) and amyloid (Aβ) plaques in the brain. Post-translational modification through ubiquitylationplays critical roles in clearing misfolded protein aggregates. Investig...
ORGANISM(S): Homo sapiens (Human) 
2019-06-25 | PXD009199 | Pride
Ubiquitylome Ad Gg remnant peptides 
ProteomicsProteomic Analysis of Ubiquitin Chain Types in Murine Cells and Tissues
Mass spectrometry-based proteomics has become an integral approach for characterising ubiquitin chain-linkage compositions and architectures. In this study, we optimised sample preparation and chromatographic separation of Ubiquitin peptides for Absolute Quantification by Parallel Reaction Monitorin...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-28 | PXD017754 | Pride
Absolute quantification Ubiquitin chain-linkage composition Murine tissues Parallel reaction monitoring 
ProteomicsPost-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases.
Posttranslational modifications with ubiquitin alter protein function and stability, thereby regulating cell homeostasis and viability, particularly under stress. Ischemic stroke induces protein ubiquitination at the periphery of the ischemic territory, wherein cells remain viable. Revealing the ide...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-06 | PXD042951 | Pride
Brain Phospho-proteomics Ubiquitin-enrichment Mouse Ischemic stroke Detergent-insoluble Nanolc-ms/ms Cerebral cortex 
UnknownAutomating UbiFast for High-throughput and Multiplexed Ubiquitin Enrichment.
Not available
S-EPMC9357436 | biostudies-literature
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