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GenomicsPromoters Active in Interphase are Bookmarked during Mitosis by Ubiquitination
We analyzed genome-wide modification of chromatin by ubiquitination in human cells and whether this mark changes through the cell cycle using modified ChIP-seq technique (ChAP-seq). Chromatin affinity purification was based on a standard ChIP method with modification of a two-step affinity purificat...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45771 | biostudies-arrayexpress
ProteomicsZnf598-mediated Rps10/eS10 Ubiquitination contributes to the ribosome ubiquitination dynamics during zebrafish development
The ribosome is a translational apparatus that comprises about 80 ribosomal proteins and four rRNAs. Recent studies reported that ubiquitination of the ribosomal proteins plays a pivotal role in translational control and ribosome-associated quality control (RQC). However, little is known about the d...
ORGANISM(S): Danio Rerio 
2023-10-11 | PXD039560 | JPOST Repository
ProteomicsCalcium-triggered (de)ubiquitination events in synapses
Neuronal communication relies on neurotransmitter release from synaptic vesicles (SVs), whose dynamics are controlled by Ca2+-dependent pathways, as many thoroughly studied phosphorylation cascades. However, little is known about other post-translational modifications, as ubiquitination. To address ...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
PXD053470 | panorama
GenomicsThe Mediator complex subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination
The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23-/- (KO) cells and ...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-59518 | biostudies-arrayexpress
ProteomicsQuantitative proteomic atlas of phosphorylation and ubiquitination reveals Epn2-mediated endocytosis dysfunction in α-synuclein transgenic mice
Progression through neuronal loss of substantia nigra pars compacta with Parkinson’s disease depends on various protein post-translational modifications mainly comprising phosphorylation, ubiquitination, acetylation, and methylation. Phosphorylation and ubiquitination regulate major physiological ch...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD013965 | Pride
Phosphorylation Ubiquitination Parkinson’s disease Quantitative proteomics Endocytosis 
ProteomicsIdentification ubiquitination of EGFR by LC-MS/MS
Previously, analysis of EGF-induced EGFR ubiquitination by mass spectrometry revealed that ubiquitinated lysine residues were located in the TKD of EGFR. However, the specific lysine residues for the CBL-mediated polyubiquitination have not been identified. To investigate the differences in EGFR ubi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024279 | Pride
Cbl Ubiquitination Znrf1 Egfr Lc-ms/ms 
ProteomicsProtein ubiquitination in Aspergillus nidulans
Protein ubiquitination, an evolutionarily conserved post-translational modification process in eukaryotes, and plays an important role in many biological processes. Aspergillus nidulans, a model filamentous fungus, contributes to our understanding of cellular physiology, metabolism and genetics, but...
ORGANISM(S): Aspergillus 
2015-09-10 | PXD002299 | Pride
Lc-msms Aspergillus nidulans Ubiquitination Mycelial dvelopment 
ProteomicsThe identification of ubiquitination sites of IBTK by shotgun proteomics
Previous study reported that eIF4A1 protein stability is subject to control by the ubiquitin-proteasome pathway, and deubiquitinase USP9X elevated eIF4A1 protein level by promoting eIF4A1 deubiquitination. However, the E3 ubiquitin ligases responsible for eIF4A1 proteolysis is not determined. Our re...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD039031 | Pride
Ibtk Ubiquitination Shotgun 
ProteomicsQuantitative proteomics reveals extensive lysine ubiquitination in Arabidopsis thaliana
In this study, we describe an antibody-based approach to enrich ubiquitinated peptides from vegetative tissues for detection via peptide mass spectrometry. This enrichment method can be coupled with isobaric labeling to enable quantification from up to 18-multiplexed samples. This approach identifie...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2024-07-31 | MSV000095496 | MassIVE
TranscriptomicsExpression data from 17 day old testes of wild type and UBR2-/- mice
Ubiquitylation of histones provides an important mechanism regulating chromatin remodeling and gene expression. Recent studies have revealed ubiquitin ligases involved in histone ubiquitylation, yet the responsible enzymes and the function of histone ubiquitination in spermatogenesis remain unclear....
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-18824 | biostudies-arrayexpress
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