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ProteomicsHsp90i resistance - Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
The goal is to describe the mechanisms underlying the resistance of melanoma against Hsp90i using (phospho)proteomics
ORGANISM(S): Homo sapiens (Human) 
2018-02-26 | PXD005518 | Pride
Proteomics  phosphoproteomics  lc/ms/ms  hsp90i 
ProteomicsEnhanced validation of antibodies for research applications
There is a need for standardized validation methods for antibody specificity and selectivity. Recently, five alternative validation “pillars" were proposed to explore the specificity of research antibodies using methods with no need for prior knowledge about the protein target. Here, we show that th...
ORGANISM(S): Homo sapiens (Human) 
2018-08-21 | PXD010178 | Pride
Western blot Sds-page U251 Rt4 Lc-msms 
ProteomicsWestern blot validation - The goal is to define guidelines for Ab western blot validation
The goal is to define guidelines for Ab western blot validation
ORGANISM(S): Homo sapiens (Human) 
2018-08-21 | PXD005914 | Pride
Wester blot Tmt Prm Transcriptomics 
ProteomicsCETSA Hsp90i - Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
The goal of this project is to identify the drug target of XL888, an hsp90i used in clinical trial against melanoma
ORGANISM(S): Homo sapiens (Human) 
2018-02-13 | PXD005508 | Pride
Cetsa-ms  brp  lc/ms/ms 
ProteomicsphosphoCETSA - Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
The goal of this project is to study the mechanisms of resistance to Hsp90i using phosphoCETSA-MS
ORGANISM(S): Homo sapiens (Human) 
2018-02-26 | PXD005547 | Pride
Phosphocetsa  lc/ms/ms  tmt 
ModelsMardinoglu2014 - Genome-scale metabolic model (HMR version 2.0) - human hepatocytes (iHepatocytes2322)
Mardinoglu2014 - Genome-scale metabolic model (HMR version 2.0) - human hepatocytes (iHepatocytes2322) This model is described in the article: Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. Mardinog...
2005-01-01 | MODEL1402200003 | BioModels
ProteomicsProteomics profiling of the cell cycle provides novel insight in dynamics of protein turnover, phosphorylation and subcellular localization.
The goal is to provide a system-level understanding of the dynamics of the cell cycle using complementary approaches such as Proteomics, phosphoproteomics and functional genomics.
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD011836 | Pride
Proteomics Fractionation Cell cycle Phosphoproteomics 
TranscriptomicsTranscription profiling of autumn senescence in populus Leaves
Gene expression profiling in leaves of a free-growing aspen tree (Populus tremula) in Umea in northern Sweden during natural autumn senescence (from August 17 to September 21).
ORGANISM(S): Populus tremula 
2004-03-09 | E-MEXP-93 | biostudies-arrayexpress
ModelsUhlén2015 - Human tissue-based proteome metabolic network - lymph node
Uhlén2015 - Human tissue-based proteome metabolic network - lymph node Human lymph node specific proteome metabolic network This model is described in the article: Tissue-based map of the human proteome Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinogl...
2015-01-28 | MODEL1411240016 | BioModels
ModelsUhlén2015 - Human tissue-based proteome metabolic network - stomach
Uhlén2015 - Human tissue-based proteome metabolic network - stomach Human stomach specific proteome metabolic network This model is described in the article: Tissue-based map of the human proteome Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, S...
2015-01-28 | MODEL1411240017 | BioModels
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