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ProteomicsQuantitative proteomics of barrier-deficient mouse epidermis in response to environmental humidity
Low environmental humidity aggravates symptoms of inflammatory skin diseases, e.g. of Atopic Dermatitis (AD). Using mice that develop AD-like symptoms, we show that an increase in environmental humidity rapidly rescues their cutaneous inflammation and associated epidermal abnormalities. Quantitative...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-14 | PXD007124 | Pride
Mouse Skin Barrier defect Humidity Epidermis Osmoregulation 
ProteomicsAtopic dermatitis epidermis PCT-DIA
Atopic Dermatitis (AD) is the most common inflammatory skin disease and characterized by a deficient epidermal barrier and cutaneous inflammation. Genetic studies suggest a key role of keratinocytes in AD pathogenesis, but the alterations in the proteome that occur in the entire epidermis have not b...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD025431 | Pride
Pressure cycling technology Atopic dermatitis Data-independent acquisition Epidermis 
ProteomicsQuantitative proteomics analysis of lung tissue from E18.5 embryos with mesenchymal deletion of VLK
Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a broad range of secretory pathway-resident and extracellular matrix proteins. However, its cell-type specific functions in vivo are still largely unknown. Therefore, we generated m...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-11 | PXD037700 | Pride
Embryo Lung Vertrebrate lonesome kinase 
TranscriptomicsTranscription profiling of mouse Nrf2 knockout caused by ROS-mediated insulin/IGF-1 resistance
The liver is frequently challenged by surgery-induced metabolic overload, viruses, or toxins, which induce the formation of reactive oxygen species. To determine the effect of oxidative stress on liver regeneration and to identify the underlying signalling pathways, we studied liver repair in mice l...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8969 | biostudies-arrayexpress
UnknownRivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease.
Not available
S-EPMC11198259 | biostudies-literature
UnknownSecond asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy.
Not available
S-EPMC8473558 | biostudies-literature
UnknownSearch for heavy neutrinos and [Formula: see text] bosons with right-handed couplings in proton-proton collisions at [Formula: see text].
Not available
S-EPMC4371073 | biostudies-literature
UnknownSearch for supersymmetry in pp collisions at [Formula: see text] TeV in events with a single lepton, jets, and missing transverse momentum.
Not available
S-EPMC4370766 | biostudies-literature
UnknownMeasurement of the differential cross section for top quark pair production in pp collisions at [Formula: see text].
Not available
S-EPMC4657759 | biostudies-literature
UnknownEfficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
Not available
S-EPMC5731244 | biostudies-literature
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