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ProteomicsNAD metabolism modulates mitochondrial function and inflammation and prevents progression of diabetic kidney disease
Background: Diabetes mellitus is the leading cause of cardiovascular and renal disease in the United States. In spite of all of the beneficial interventions implemented in patients with diabetes, there remains a need for additional therapeutic targets in diabetic kidney disease (DKD). Mitochondrial ...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-02 | PXD029745 | Pride
Nr Kidney Diabetes Dbdb 
ProteomicsWide Window Acquisition and AI-based data analysis to reach deep proteome coverage for a wide sample range, including single cell proteomic inputs – Co-immunoprecipitation samples
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yielded impressive results, current studies suffer from a limited proteomic depth and dynamic range therefore ...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-13 | PXD037985 | Pride
Mus musculus Co-immunoprecipitation Micropillar array chromatography Smarca5 Orbitrap exploris 480 Ultimate3000 rslcnano Protein-protein interactions Trap-and-elute 
ProteomicsDinoflagellates contribute to primary and secondary production across biogeochemical gradients of the central Pacific Ocean
In this study we explored the metabolism of unicellular eukaryotic organisms (protists) across a 4,600 km meridional transect in the central Pacific Ocean. The region contains a natural biogeochemical gradient spanning from low nitrogen, oligotrophic waters to a productive equatorial upwelling syste...
ORGANISM(S): phytoplankton environmental sample 
2020-09-18 | PXD014230 | Pride
Phytoplankton Pacific ocean Dinoflagellates 
ProteomicsSynGAP variant from Japanese ALS cohort alters the recruitment of RNA binding proteins
FUS is one of the pathogenic RNA-binding proteins for amyotrophic lateral sclerosis (ALS). We previously reported that FUS stabilized SynGAP mRNA at its 3’UTR and maintained spine maturation and cognitive function in mice. To elucidate whether this mechanism could be pathogenic for ALS, we identifie...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026586 | Pride
Ipsc Motor neuron Als Fus Syngap 
ProteomicsOnline Nanoflow Two-Dimension Comprehensive Active Modulation Reversed Phase-Reversed Phase Liquid Chromatography High Resolution Mass Spectrometry for Metaproteomics of Environmen-tal and Microbiome Samples
Metaproteomics is a powerful analytical approach that can assess the functional capabilities deployed by microbial communi-ties in both environmental and biomedical microbiome settings. Yet the mass spectra resulting from these mixed biological communities are challenging due to the high number of l...
ORGANISM(S): Homo sapiens (Human) marine plankton environmental sample 
2022-05-20 | PXD027351 | Pride
Automated Metaproteomics Proteomics Comprehensive active modulation 2dlc Rprp Lc Ocean Lcms 
ProteomicsMicrobial anti-inflammatory Molecule is a key protein processed and exported to Faecalibacterium duncaniae envelope
MAM (Microbial-Anti-Inflammatory Molecule) is a 14,5 kDa protein that is one of the best-known effector molecules with anti-inflammatory properties in Faecalibacterium duncaniae, a critical species in the human gut microbiota. Despite its importance, MAM function and molecular features remain poorly...
ORGANISM(S): Faecalibacterium prausnitzii A2-165 
2025-06-30 | PXD057939 | Pride
Proteomic and peptidomic 
ProteomicsNAD+/NADH Redox Alterations Reconfigure Metabolism and Rejuvenate Senescent Human Mesenchymal Stem Cells In Vitro
Human mesenchymal stem cells (hMSCs) promote endogenous tissue regeneration and have become a promising candidate for cell therapy. However, in vitro culture expansion of hMSCs induces a rapid decline of stem cell properties through replicative senescence. Here we characterize metabolic profiles of...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022395 | Pride
Msc 
ProteomicsComparative proteomics of the calcified red alga under different CO2 treatments
Thalli of calcified red macroalga A. fragilissima were grown at different pCO2 conditions; low, medium, and high pCO2 (400, 1,000 and 1,600 ppm).
ORGANISM(S): Amphiroa fragilissima 
2025-05-06 | PXD033648 | Pride
Tmt Proteomics，calcified algae 
ProteomicsComparative proteomics of the calcified green alga under different CO2 treatments
Thalli of calcified red macroalga Halimeda opuntia were grown at different pCO2 conditions; low, medium, and high pCO2 (400, 1,000 and 1,600 ppm).
ORGANISM(S): Halimeda opuntia 
2025-05-06 | PXD033672 | Pride
Proteomics Light Co2 Calcified alga 
ProteomicsHypoxia response in barley - proteomics analysis
Hypoxia stress (<1% oxygen) followed by reoxygenation, is accompanied by formation of reactive oxygen species (ROS) and nitric oxide (NO), which act as signaling molecules, but also cause nitro-oxidative stress. The NO concentration is regulated by phytoglobins (formerly hemoglobins) in the NO cycle...
ORGANISM(S): Hordeum vulgare (Barley) 
2020-03-02 | PXD017103 | Pride
Barley Hypoxia Lc-ms/ms 
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