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MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
ProteomicsUltra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation
Single-cell technologies are revolutionizing biology but are today mainly limited to imaging and deep sequencing. However, proteins are the main drivers of cellular function and in-depth characterization of individual cells by mass spectrometry (MS)-based proteomics would thus be highly valuable and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD024043 | Pride
Proteomics at single-cell resolution  low flow lc-ms  drug perturbation  systems biology  single-cell heterogeneity 
ProteomicsExtending proteome coverage through an on-line 2D SCX-RP ultra-high pressure system
Ultra high pressure liquid chromatography (UHPLC) systems combined with state of the art mass spectrometers have pushed the limit of deep proteome sequencing to new heights making it possible to identify thousands of proteins in a single LC/MS experiment within a few hours. However, the relationship...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080845 | MassIVE
UnknownUltra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation.
Not available
S-EPMC8884154 | biostudies-literature
ProteomicsoptiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material
Personalized cancer immunotherapies such as vaccines and T cell receptor (TCR)-transgenic T cells rely on the presentation of tumor-specific peptides by human leukocyte antigen (HLA) class I molecules to cytotoxic T cells. Such neoepitopes can for example arise from somatic mutations and their ident...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD043542 | Pride
Immunopeptidomics Prm Lc-ms Targeted ms 
ProteomicsA multi-species spike-in sample set for performance evaluation of label-free proteomics quantification
When evaluating the quantitative performance of label-free proteomics method(s), samples with known compositions are necessary to define key parameters such as reproducibility, missing data levels, accuracy, precision, as well as sensitivity/specificity for biomarker discovery. Here, we provide a ca...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2022-01-06 | PXD030780 | Pride
Performance evaluation Label-free quantification Ionstar 
ProteomicsDISCO-MS: Proteomics of spatially identified tissues in whole organs
Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. Liquid chromatography coupled to mass spectrometry (LC-MS) is emerging as a key technology for the unbiased characterization of proteins, the drivers of cellular fun...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-11-27 | PXD025316 | Pride
Ultra-high sensitivity proteomics  proteomics  tissue-clearing  solvent-clearing  familial alzheimer’s disease  mild traumatic brain injury  imaging  spatial proteomics 
ProteomicsRapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment Analysis
Reliable, robust, large-scale molecular testing for SARS-CoV-2 is essential for monitoring the ongoing Covid-19 pandemic. We have developed a scalable analytical approach to detect viral proteins based on peptide immunoaffinity enrichment combined with liquid chromatography - mass spectrometry (LC-M...
ORGANISM(S): Homo Sapiens Severe Acute Respiratory Syndrome Coronavirus 2 
2021-11-15 | PXD026366 | panorama
ProteomicsAn ultra-high-resolution IonStar strategy enhancing accuracy and precision of MS1-based proteomics and an extensive comparison with state-of-the-art SWATH-MS in large-cohort quantification
Quantitative proteomics in large cohorts is highly valuable for biomedical/pharmaceutical investigations but often suffers from suboptimal reliability, accuracy, and reproducibility. Here we describe a new ultra-high-resolution (UHR) IonStar method achieving precise/reproducible protein measurement ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2021-06-24 | PXD017915 | Pride
Ultrahigh resolution ionstar 240k quantification 
ProteomicsAn ultra-high-resolution IonStar strategy enhancing accuracy and precision of MS1-based proteomics and an extensive comparison with state-of-the-art SWATH-MS in large-cohort quantification
Quantitative proteomics in large cohorts is highly valuable for biomedical/pharmaceutical investigations but often suffers from suboptimal reliability, accuracy, and reproducibility. Here we describe a new ultra-high-resolution (UHR) IonStar method achieving precise/reproducible protein measurement ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2021-06-24 | PXD017812 | Pride
Ultrahigh resolution ionstar Swath-ms 120k technical replicates 
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