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ProteomicsMechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates, as well as mitotic DNA intertwinements, yet how its diverse activities are regulated remains unclear. Here, we identify key determinants of stable assembly of the BTRR complex on ultrafine DNA bridges (U...
ORGANISM(S): Homo sapiens (Human) 
2026-07-30 | PXD081930 | Pride
Bloom syndrome complex Ultrafine dna bridges 
UnknownBLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
Not available
S-EPMC1933408 | biostudies-literature
UnknownTopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability.
Not available
S-EPMC3882784 | biostudies-literature
Unknown53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process.
Not available
S-EPMC5813243 | biostudies-literature
ProteomicsCentromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo transient mi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD064192 | Pride
Chromosome biorientation Bloom syndrome helicase Cdk1 Mps1 Pich Plk1 Ultrafine dna bridge (ufb)-binding complex Pp1s Rif1 Anaphase dna bridges Centromeres Btrr dissolvasome 
ProteomicsCentromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo transient mi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD052669 | Pride
Chromosome biorientation Bloom syndrome helicase Cdk1 Mps1 Pich Plk1 Ultrafine dna bridge (ufb)-binding complex Pp1s Rif1 Anaphase dna bridges Centromeres Btrr dissolvasome 
ProteomicsCentromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo transient mi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-27 | PXD052850 | Pride
Chromosome biorientation Bloom syndrome helicase Cdk1 Mps1 Pich Plk1 Ultrafine dna bridge (ufb)-binding complex Pp1s Rif1 Anaphase dna bridges Centromeres Btrr dissolvasome 
UnknownUltrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier.
Not available
S-EPMC3159475 | biostudies-literature
ProteomicsThe FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin
Joint DNA molecules are natural by-products of DNA replication and repair. Persistent joint molecules give rise to ultrafine DNA bridges (UFBs) in mitosis, which compromise sister chromatid separation. The DNA translocase PICH (ERCC6L) plays a central role in UFB resolution. To better understand the...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD035876 | Pride
Homologous recombination rad51 c1orf112 dna repair flag ip 
UnknownThe interplay of the translocase activity and protein recruitment function of PICH in ultrafine anaphase bridge resolution and genomic stability.
Not available
S-EPMC11797016 | biostudies-literature
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