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UnknownPhase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer.
Not available
S-EPMC3577951 | biostudies-literature
TranscriptomicsMetabolic modeling of antibiotic and cytotoxic effects of the isoquinoline IQ-238 in S. aureus, S. epidermidis and human cells
Isoquinolines (IQs) are natural substances with antibiotic potential. IQ-238 is a synthetic analog of the novel-type N,C-coupled naphtylisoquinoline (NIQ) alkaloid ancisheynine. Gene expression data, cytotoxicity measurements and metabolic modelling is combined to assess the effects of the N,C-coup...
ORGANISM(S): Staphylococcus aureus 
2015-04-30 | E-GEOD-33832 | biostudies-arrayexpress
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR) [expression]
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-47945 | biostudies-arrayexpress
ProteomicsChaperonic function of a C/D snoRNA dictates the structure and function of translating ribosomes
Leishmania cause cutaneous and visceral diseases affecting millions worldwide. The parasite cycle between insect and mammalian hosts. In this study, we determined the landscape of this 2’-O- methylation (Nm) modification on the rRNA and found that two positions change during cycling between its two ...
ORGANISM(S): Leishmania major strain Friedlin 
2026-06-02 | PXD052150 | Pride
Cryo-em Ribosome Chaperon Snorna Translation 
UnknownDefined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.
Not available
S-EPMC5501412 | biostudies-literature
TranscriptomicsModel matters: differences in orthotopic rat hepatocellular carcinoma physiology determine therapy response to sorafenib
Purpose: Preclinical model systems should faithfully reflect the complexity of the human pathology. In hepatocellular carcinoma (HCC), the tumor vasculature is of particular interest in diagnosis and therapy. By comparing two commonly applied preclinical model systems, diethylnitrosamine induced (DE...
ORGANISM(S): Rattus norvegicus 
2016-03-25 | E-MTAB-3507 | biostudies-arrayexpress
TranscriptomicsDistinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses [Expt: ChIP-chip]
We performed a set of microarray and chromatin-immunoprecipitation (ChIP)-chip experiments using siRNA against the (pro)renin receptor ((P)RR), stable overexpression of PLZF, the PLZF translocation inhibitor genistein and the specific V-ATPase inhibitor bafilomycin to dissect transcriptional pathway...
ORGANISM(S): Homo sapiens 
2013-07-05 | E-GEOD-39960 | biostudies-arrayexpress
UnknownRegulatory modules controlling maize inflorescence architecture.
Not available
S-EPMC3941108 | biostudies-literature
GenomicsExpression profile and RNA Polymerase II occupancy of transposable elements among knock down of the piRNA pathway components in OSCs
The PiwiM-bM-^@M-^SpiRNA complex (PiwiM-bM-^@M-^SpiRISC) in Drosophila ovarian somatic cells represses transposons transcriptionally to maintain genome integrity; however, the underlying mechanisms remain obscure. We performed mRNA-seq analysis from OSCs transfected with siRNAs against CG3893, the k...
ORGANISM(S): Drosophila melanogaster 
2013-08-01 | E-GEOD-47006 | biostudies-arrayexpress
TranscriptomicsDistinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses [Expt: Geni_Bafi]
Within the overall project, we performed a set of microarray and chromatin-immunoprecipitation (ChIP)-chip experiments using siRNA against the (pro)renin receptor ((P)RR), stable overexpression of PLZF, the PLZF translocation inhibitor genistein and the specific V-ATPase inhibitor bafilomycin to dis...
ORGANISM(S): Homo sapiens 
2013-07-05 | E-GEOD-39962 | biostudies-arrayexpress
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