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ProteomicsYeast phosphofructokinase subunit 2 has ATP-dependent RNA unwinding activity and modulates cell cycle progression
Phosphofructokinase (PFK) is a rate-limiting glycolytic enzyme that also possesses an unexplored polyadenylated RNA binding activity. Here, we show that the two PFK subunits, Pfk1 and Pfk2, in budding yeast bind a large number of mRNAs in cells, including ones coding for proteins involved in regulat...
ORGANISM(S): Saccharomycetales (ncbitaxon:4892) 
2024-12-04 | MSV000096586 | MassIVE
GenomicsStepwise DNA unwinding gates TnpB genome-editing activity
Stepwise DNA unwinding gates TnpB genome-editing activity
PRJNA1450085 | ENA
ProteomicseIF4A1 unwinding activity is RNA sequence-specifically deployed through eIF4A1-multimerisation to facilitate translation of mRNAs with local repressive RNA structure
Oncogenic translational programmes are an emerging hallmark of cancer and often driven by dysregulation of signaling pathways including KRAS and mTORC that converge on the eukaryotic translation initiation (eIF) 4F complex. Altered eIF4F activity promotes translation of oncogene mRNAs that typically...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD034343 | Pride
Proteomics Tmt Eif4a1 Pulse silac 
TranscriptomicsStepwise DNA unwinding gates TnpB genome-editing activity
TnpB is a compact RNA-guided endonuclease and evolutionary ancestor of CRISPR-Cas12 that offers a promising platform for genome engineering. However, the genome-editing activity of TnpBs remains limited and its underlying determinants are poorly understood. Here, we used biochemical and single-molec...
ORGANISM(S): Escherichia coli 
2026-04-17 | GSE327273 | GEO
UnknownUnwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase.
Not available
S-EPMC4402530 | biostudies-literature
UnknownDNA Unwinding Driven by Gold Nanoparticles.
Not available
S-EPMC12735733 | biostudies-literature
ProteomicsBLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures
Bloom’s syndrome (BLM) protein is a known nuclear helicase that is able to unwind DNA secondary structures such as G-quadruplexes. However, its role in the regulation of cytoplasmic processes that involve RNA G-quadruplexes (rG4s) has not been previously studied. Here, we demonstrate that BLM is rec...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039534 | Pride
Stress granule Apex Helicase Lc-msms G-quadruplex Rg4-binding proteins Blm Quma-1 
UnknownUS Coverage Changes During Medicaid Unwinding in 2023.
Not available
S-EPMC12514626 | biostudies-literature
UnknownRepetitive RNA unwinding by RNA helicase A facilitates RNA annealing.
Not available
S-EPMC4117756 | biostudies-literature
UnknownUnwinding initiation by the viral RNA helicase NPH-II.
Not available
S-EPMC3267895 | biostudies-literature
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