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ProteomicsMitochondrial ribosomal RNA is the target of functionally dominant hotspot mutations in cancer
The vast majority of recurrent somatic mutations arising in tumors affect protein-coding genes in the nuclear genome. Here, through population-scale analysis of 14,079 whole tumor genomes, we report the discovery of highly recurrent mutations affecting both the small (12S, MT-RNR1) and large (16S, M...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD057390 | Pride
Mitochondrial dna mutation Heteroplasmy Cancer Mt-rnr1 M.1227g>a 
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD039705 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade (part 2)
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD044987 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
ProteomicsTranscriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma
Background: Epigenetic alterations play an increasingly recognized role in carcinogenesis and in the development of resistance to anticancer therapies. Epigenetic enzymes (writers and erasers) and effectors (readers) are largely influenced by the availability of metabolites grenerated through one-ca...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD072211 | Pride
Metabolism Mouse models Epigenetics Drug targets Cholangiocarcinoma 
UnknownPrediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial.
Not available
S-EPMC7467153 | biostudies-literature
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