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TranscriptomicsTranscriptomic analysis of human cybrid cell lines harboring increasing levels of the mitochondrial DNA (mtDNA) 3243A>G mutation
Mitochondria generate signals of adaptation that regulate nuclear genes expression via retrograde signaling. But this phenomenon is complexified when qualitatively different mitochondria and mitochondrial DNA (mtDNA) coexist within cells. Although this cellular state of heteroplasmy leads to diver...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-56158 | biostudies-arrayexpress
ProteomicsAsparagine Auxotrophy Regulates the Integrated Stress Response in Cells with mtDNA Heteroplasmy
Mitochondrial DNA (mtDNA) heteroplasmy modulates cellular respiration and proliferation. Cells with high levels of mtDNA heteroplasmy display asparagine auxotrophy. To investigate how the asparagine availability influences the protein profile, we performed proteomic analysis on heteroplasmic cells c...
ORGANISM(S): Homo sapiens (Human) 
2026-09-24 | PXD065861 | Pride
Heteroplasmy Atf4 Integrated stress response Mitochondrial dna Asparagine 
GenomicsMitochondrial heteroplasmy in vertebrates using ChIP-sequencing data
Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data
PRJEB11182 | ENA
GenomicsMitochondrial heteroplasmy in vertebrates using ChIP-sequencing data
Mitochondrial heteroplasmy, the presence of more than one mtDNA variant in a cell or individual is not as uncommon as previously thought. It is mostly due to the high mutation rate of the mtDNA and limited repair mechanisms present in the mitochondrion. The phenomenon has been studied mostly in huma...
ORGANISM(S): Heterocephalus glaber 
2016-05-13 | E-MTAB-3933 | biostudies-arrayexpress
TranscriptomicsHeteroplasmy between wild type mitochondrial DNA variants is detrimental and shorten life span
We evaluated here the physiological consequences of the generation of heteroplasmic embryos by mix of two wild type mtDNAs in the same zygote. In this animal model, mtDNA heteroplasmy is actively combated during germ-line transmission, embryonic development and somatic life of most differentiated ce...
ORGANISM(S): Mus musculus 
2020-01-01 | GSE93920 | GEO
UnknownHeteroplasmy in the complete chicken mitochondrial genome.
Not available
S-EPMC6839896 | biostudies-literature
GenomicsRewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control
Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control
PRJNA1282634 | ENA
UnknownNuclear genome-wide associations with mitochondrial heteroplasmy.
Not available
S-EPMC7968846 | biostudies-literature
GenomicsWHOLE MITOGENOME SEQUENCING UNCOVERS A RELATION BETWEEN MITOCHONDRIAL HETEROPLASMY, OXIDATIVE PHOSPHORYLATION AND LEPROSY SEVERITY
WHOLE MITOGENOME SEQUENCING UNCOVERS A RELATION BETWEEN MITOCHONDRIAL HETEROPLASMY, OXIDATIVE PHOSPHORYLATION AND LEPROSY SEVERITY
PRJEB59275 | ENA
UnknownNeutral mitochondrial heteroplasmy and the influence of aging.
Not available
S-EPMC3063991 | biostudies-literature
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