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GenomicsSRSF7-mediated Alternative Splicing of USO1 Promotes Hepatocellular Carcinoma by Activating the MAPK/ERK1-ELK1 Pathway
SRSF7-mediated Alternative Splicing of USO1 Promotes Hepatocellular Carcinoma by Activating the MAPK/ERK1-ELK1 Pathway
PRJNA1092805 | ENA
TranscriptomicsSRSF7-mediated Alternative Splicing of USO1 Promotes Hepatocellular Carcinoma by Activating the MAPK/ERK1-ELK1 Pathway
We conducted a transcriptome-wide survey to identify novel hepatocellular carcinoma (HCC)-associated genes that have undergone aberrant alternative splicing. We revealed that the vesicle transport factor (USO1) is a major alternatively spliced target in HCC, mainly composed of a long wild-type isofo...
ORGANISM(S): Homo sapiens 
2024-04-02 | GSE262667 | GEO
UnknownUSO1 expression is dysregulated in non-small cell lung cancer.
Not available
S-EPMC9554690 | biostudies-literature
UnknownUSO1 Coordinates Centriolar Satellites to Regulate Male Germ Cell Proliferation and Cell Cycle Progression.
Not available
S-EPMC12072129 | biostudies-literature
UnknownCrystal structures of Uso1 membrane tether reveal an alternative conformation in the globular head domain.
Not available
S-EPMC7293329 | biostudies-literature
UnknownFocused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.
Not available
S-EPMC8222245 | biostudies-literature
UnknownThe Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain.
Not available
S-EPMC10275640 | biostudies-literature
ProteomicsIdentification of p115 interacting proteins from HEK293T cells
The protein p115 is a key player in the delivery of vesicles from the endoplasmic reticulum to the early Golgi. The protein is a homodimer with a folded head domain and a coiled-coil tail that is anchored to Golgi membranes. p115 has been shown to capture vesicles and to bind to SNARE proteins to p...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD075617 | Pride
Human Lc-msms P115 Uso1 Hek293t Sec16a 
UnknownIdentification of RNA-splicing factor Lsm12 as a novel tumor-associated gene and a potent biomarker in Oral Squamous Cell Carcinoma (OSCC).
Not available
S-EPMC9027881 | biostudies-literature
ProteomicsEXPLORING THE INTERACTOME OF PML NUCLEAR SUBDOMAINS DURING FATTY ACID STRESS USING APEX2-MEDIATED PROXIMITY LABELING
When exposed to excess fatty acids, specific cell types produce nuclear lipid droplets (nLDs) that associate with promyelocytic leukemia (PML) protein to form Lipid Associated PML Structures (LAPS) that are enriched in lipid biosynthetic enzymes but deficient in canonical proteins associated with PM...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053509 | Pride
Nuclear lipid droplet Promyelocytic leukemia Copii Proximity-dependent biotin identification Apex2 Lipid-associated pml structures 
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