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ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040477 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040473 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
ProteomicsThe circadian clock output deubiquitylating enzyme USP2-45 regulates intestinal Ca2+ absorption
In order to identify molecular targets of USP2-45 in the small intestine, we carried out a quantitative proteomics iTraq (Isobaric tag for relative and absolute quantitation) screen to compare proteins from WT and knockout mice. With this analysis we identified, among others, the scaffolding prote...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-22 | PXD000659 | Pride
Intestinal calcium absorption Mass spectrometry Isobaric tagging Circadian clock Ubiquitin-specific protease 2 
UnknownTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy.
Not available
S-EPMC10079682 | biostudies-literature
UnknownLncRNA USP2-AS1 Promotes Hepatocellular Carcinoma Growth by Enhancing YBX1-Mediated HIF1α Protein Translation Under Hypoxia.
Not available
S-EPMC9174509 | biostudies-literature
UnknownCD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.
Not available
S-EPMC12815083 | biostudies-literature
UnknownThe deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer.
Not available
S-EPMC7429833 | biostudies-literature
UnknownTransient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate.
Not available
S-EPMC3617563 | biostudies-literature
UnknownIdentification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease.
Not available
S-EPMC7487165 | biostudies-literature
UnknownUnderstanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2.
Not available
S-EPMC5355956 | biostudies-literature
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