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ProteomicsHuman HEK293T cell LC-MS/MS to identify the phosphorylation site of USP8
Research has shown that phosphorylation can regulate the enzymatic activity of USP8. Therefore, we attempted to identify the phosphorylation sites of USP8.
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD059969 | Pride
Human Hek293t Usp8 
ProteomicsFLAG-Ub IP/MS of USP8-depleted cells
The analysis to identify ubiquitinated proteins increased on endosomes in USP8-depleted cells.
ORGANISM(S): Homo sapiens (Human) 
2023-12-17 | PXD042488 | Pride
Ubiquitin Endosome Usp8 
ProteomicsTMT 6-plex proteome analyisis of USP8-depleted cells
The analysis to investigate the change in proteome of USP8-depleted cells
ORGANISM(S): Homo sapiens (Human) 
2023-12-17 | PXD042490 | Pride
Ubiquitin Endosome Usp8 
GenomicsTranscriptome profiling of wild-type (WT) and USP8 knockout (KO) CT26 cell lines
Transcriptome profiling of wild-type (WT) and USP8 knockout (KO) CT26 cell lines
PRJNA691207 | ENA
GenomicsUSP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development
USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development
PRJNA1292019 | ENA
TranscriptomicsTranscriptome profiling of wild-type (WT) and USP8 knockout (KO) CT26 cell lines
USP8 is one of DUBs and is frequently overexpressed or gain-of-function mutated in multiple types of human cancer. Importantly, USP8 has been identified as an immunomodulatory DUB as T cell-specific Usp8 deficiency disrupts regulatory T cell functions, leading to recruiting abundant CD8+ T cells in ...
ORGANISM(S): Mus musculus 
2022-02-14 | GSE164558 | GEO
TranscriptomicsUSP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development
Aberrant protein regulatory pathways disrupt bone homeostasis and contribute to skeletal diseases. Many of cysteine protease family of deubiquitinating enzymes (DUBs) are critical for regulation of bone-resorbing osteoclasts and bone-forming osteoblasts. Here, we demonstrate that the DUB ubiquitin-s...
ORGANISM(S): Mus musculus 
2026-03-05 | GSE302739 | GEO
GenomicsUSP8 coordinates ESCRT-mediated membrane repair, xenophagy, and oxidative stress responses during Mycobacterium tuberculosis infection
USP8 coordinates ESCRT-mediated membrane repair, xenophagy, and oxidative stress responses during Mycobacterium tuberculosis infection
PRJNA1003457 | ENA
TranscriptomicsUSP8 coordinates ESCRT-mediated membrane repair, xenophagy, and oxidative stress responses during Mycobacterium tuberculosis infection
We show that USP8 colocalizes with intracellular Mtb, recognizes phagosomal membrane damage, and is required for ESCRT-dependent membrane repair. Furthermore, USP8 regulates the NRF2-dependent antioxidant signature. Taken together, our study shows a central role of USP8 in promoting intracellular gr...
ORGANISM(S): Mus musculus 
2024-08-07 | GSE240372 | GEO
UnknownEndothelial USP8 is essential for angiogenesis.
Not available
S-EPMC12852293 | biostudies-literature
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